Blood Res.  2023 Mar;58(1):79-82. 10.5045/br.2023.2023039.

https://doi.org/10.5045/br.2023.2022200 CD5+ follicular lymphoma rapidly transformed to high-grade B-cell lymphoma with double-hit: from BCL2 to MYC disruption

• Soler-Espejo E
• Marco-Ayala J
• Chen-Liang TH
• López-Poveda MJ
• Teruel-Montoya R
• Ortuño FJ

• KMID: 2541069
• DOI: http://doi.org/10.5045/br.2023.2023039

Figure

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  Fig. 1 At diagnosis: (A) Bone marrow aspiration, May Grunwald-Giemsa (MGG) staining, ×100. (B) Lymph node biopsy, CD5 (main) and Bcl-2 (small panel) detection by immunohistochemistry staining, ×10. (C) Bcl-2 detection by in situ hybridization (DC/DF Metasystems). (D) FR1 clonality by Immunoglobin heavy chain gene clonality assay (IdentiClone). At high-grade B-cell lymphoma phase: (E) Bone marrow aspiration (main) and pleural fluid (small panel), MGG, ×100. (F) Retroperitoneal mass biopsy, Myc (main) and Bcl-2 (small panel) detection by immuno-histochemistry staining, ×10. (G) c-Myc detection by in situ hybridization (DC/DF TC Metasystems). (H) FR1 clonality by Immunoglobin heavy chain gene clonality assay (IdentiClone).

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  Fig. 2 Immunophenotype of lymph node at diagnosis.

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