Pediatr Infect Vaccine.  2022 Aug;29(2):105-109. 10.14776/piv.2022.29.e11.

Successful Treatment of VancomycinResistant Enterococcus Bacteremia With a Combination of Daptomycin and Tigecycline in an Infant who Underwent Heart-Lung Transplantation

Affiliations
  • 1Department of Pediatrics, Pusan National University Children’s Hospital, Yangsan, the Republic of Korea

Abstract

The treatment of invasive infections caused by multidrug-resistant vancomycin-resistant enterococci (VRE) is challenging, particularly in pediatric patients with underlying medical conditions. Newer antibiotics used to treat VRE infections in pediatric patients are insufficiently studied. This report presents the case of a 6-month-old infant who underwent heart–lung transplantation and was successfully treated with a combination of daptomycin and tigecycline for recurrent VRE bacteremia shortly after the discontinuation of linezolid.

Keyword

Vancomycin; Enterococcus faecium; Bacteremia; Daptomycin; Tigecycline
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