Tissue Eng Regen Med.
2022 Apr;19(2):205-219. 10.1007/s13770-021-00403-7.
Tumor Microenvironment Modulating Functional Nanoparticles for Effective Cancer Treatments
- Affiliations
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- 1Department of Biomedical-Chemical Engineering and Biotechnology, The Catholic University of Korea, 43 Jibongro, Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea
- 2Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea
- 3Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, People’s Republic of China
- 4Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027, Zhejiang, People’s Republic of China
- 5National Center for Translational Medicine, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China
- KMID: 2528119
- DOI: http://doi.org/10.1007/s13770-021-00403-7
Abstract
- Cancer is one of the major diseases that threaten human life worldwide. Despite advances in cancer treatment techniques, such as radiation therapy, chemotherapy, targeted therapy, and immunotherapy, it is still difficult to cure cancer because of the resistance mechanism of cancer cells. Current understanding of tumor biology has revealed that resistance to these anticancer therapies is due to the tumor microenvironment (TME) represented by hypoxia, acidity, dense extracellular matrix, and immunosuppression. This review demonstrates the latest strategies for effective cancer treatment using functional nanoparticles that can modulate the TME. Indeed, preclinical studies have shown that functional nanoparticles can effectively modulate the TME to treat refractory cancer. This strategy of using TMEs with controllable functional nanoparticles is expected to maximize cancer treatment efficiency in the future by combining it with various modern cancer therapeutics.
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