J Korean Diabetes.  2021 Jun;22(2):97-104. 10.4093/jkd.2021.22.2.97.

Recent Perspective on Thiazolidinedione

• Kim WJ

• KMID: 2526187
• DOI: http://doi.org/10.4093/jkd.2021.22.2.97

Abstract

Thiazolidinedione (TZD) is an insulin sensitizer that improves insulin resistance in the adipose tissue, liver, and muscles and has a pancreas-protective effect while inhibiting gluconeogenesis. Its other advantages include a glucose lowering effect, its durability, cardiovascular benefit, and recent evidence in nonalcoholic fatty liver disease and dementia. However, there are also concerns about fluid retention/edema/heart failure, bladder cancer, and fractures with TZD use. TZD can still be a useful option for diabetes treatment when calculating risk versus benefit, but appropriate selection of patients is needed.

Keyword

Diabetes mellitus; type 2; Hypoglycemic agents; Pioglitazone; Thiazolidinediones

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