Osteoporos Sarcopenia.  2020 Dec;6(4):212-216. 10.1016/j.afos.2020.10.001.

Lean mass and peak bone mineral density

Affiliations
  • 1Bone and Muscle Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam
  • 2Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
  • 3Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam
  • 4School of Biomedical Engineering, University of Technology Sydney, Sydney, Australia
  • 5Garvan Institute of Medical Research, Sydney, Australia

Abstract


Objectives
The association between body composition parameters and peak bone mineral density is not well documented. The aim of this study is to assess the relative contributions of lean mass and fat mass on peak bone mineral density (BMD).
Methods
The study involved 416 women and 334 men aged between 20 and 30 years who were participants in the population-based Vietnam Osteoporosis Study. Whole body composition parameters (eg, fat mass and lean mass) and BMD at the lumbar spine and femoral neck were measured by dual-energy X-ray absorptiometry. The association between lean mass and fat mass and BMD was analyzed by the linear regression model using the Least Absolute Shrinkage and Selection Operator (LASSO).
Results
Peak BMD in men was higher than women, and the difference was more pronounced at the femoral neck (average difference: 0.123 g/㎠; 95% confidence interval [CI] 0.105–0.141 g/㎠) than at the lumbar spine (average difference 0.019 g/㎠; 95% CI, 0.005–0.036 g/㎠). Results of LASSO regression indicated that lean mass was the only predictor of BMD for either men or women. Each kilogram increase in lean mass was associated with ∼0.01 g/㎠ increase in BMD. Lean mass alone explained 16% and 36% of variation in lumbar spine and femoral neck BMD, respectively.
Conclusions
Lean mass, not fat mass, is the main determinant of peak bone mineral density. This finding implies that good physical activity during adulthood can contribute to the maximization of peak bone mass during adulthood.

Keyword

Fat mass; Lean mass; Bone mineral density; LASSO; Vietnamese
Full Text Links
  • OS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr