J Clin Neurol.
2020 Oct;16(4):605-611. 10.3988/jcn.2020.16.4.605.
Causes, Risk Factors, and Clinical Outcomes of Stroke in Korean Young Adults: Systemic Lupus Erythematosus is Associated with Unfavorable Outcomes
- Kwon HS
1 - Kim YS1
- Lee JM1
- Koh SH1
- Kim HY1
- Kim C2
- Lee SH3
- Jung KH3
- Kim YD4
- Kwon HM5
- Kim BJ6
- Kim JM7
- Kim BJ8
- Heo SH9
- Chang DI9
- on Behalf of the SKY Investigators
- Affiliations
-
- 1Department of Neurology, Hanyang University College of Medicine, Seoul, Korea
- 2Department of Neurology, Hallym University Sacred Heart Hospital, Chuncheon, Korea
- 3Department of Neurology, Seoul National University Hospital, Seoul, Korea
- 4Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
- 5Department of Neurology, Seoul National University College of Medicine, Seoul Metropolitan GovernmentSeoul National University Boramae Medical Center, Seoul, Korea
- 6Department of Neurology and Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea
- 7Department of Neurology, Chung-Ang University Hospital, Seoul, Korea
- 8Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 9Department of Neurology, Kyung Hee University College of Medicine, Seoul, Korea
- KMID: 2506785
- DOI: http://doi.org/10.3988/jcn.2020.16.4.605
Abstract
- Background and Purpose
The incidence of ischemic stroke (IS) in young adults is increasing, and the associated large socioeconomic impact makes understanding IS in young adults important. We investigated the causes of and risk factors for IS in young adults, and their impact on outcomes.
Methods
The Stroke in Korean Young Adults (SKY) study is a standardized multicenter prospective study involving eight medical centers of the Republic of Korea. First-ever IS patients aged 18 years to 44 years were prospectively included in this study within 7 days of stroke onset. Their outcomes at 3 months were analyzed.
Results
This study enrolled 270 patients from April 2014 to December 2018, most (67.8%) of whom were male. About 41.5% of the patients had one or more vascular risk factors from among hypertension, diabetes mellitus, and dyslipidemia. However, only half of them had received regular treatment. Arterial dissection was more common in males, and systemic lupus erythematosus (SLE) and Moyamoya disease were more common in females. The outcome was favorable (modified Rankin Scale score of 0 or 1) in 81.9% of the patients at 3 months after stroke onset. More severe initial symptoms, higher initial glucose level, and SLE as a comorbidity were associated with unfavorable outcomes.
Conclusions
Young adult IS patients in Korea exhibit low awareness and poor management of their risk factors. Although the short-term outcome was relatively favorable in those patients, having SLE was associated with unfavorable outcomes. More attention needs to be paid for improving awareness and controlling risk factors in this population.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case Of Systemic Lupus Erythematosus Associated With Hyperthyroidism And Severe Retinopathy
- A Case of Transverse Myelitis as a First Manifestation of Systemic Lupus Erythematosus
- Three cases of premature coronary artery disease in systemic lupus erythematosus
- A Case of Lupus Enteritis That Developed during the Treatment of Systemic Lupus Erythematosus
- Multiple Dermatofibromas in a woman with Systemic Lupus Erythematosus
