Diabetes Metab J.  2019 Dec;43(6):893-897. 10.4093/dmj.2018.0254.

Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients

Affiliations
  • 1Department of Clinical Dental Sciences, Polytechnic University of Marche, Ancona, Italy.
  • 2Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy. l.tiano@univpm.it
  • 3Biomedfood s.r.l., Spinoff of Polytechnic University of Marche, Ancona, Italy.
  • 4Center of Clinical Pathology and Innovative Therapy, Italian National Research Center on Aging (IRCCS INRCA), Ancona, Italy.
  • 5Department of Clinical and Molecular Sciences, DISCLIMO, Polytechnic University of Marche, Ancona, Italy.
  • 6Clinical and Molecular Diagnostic Laboratory, IRCCS INRCA National Institute, Ancona, Italy.
  • 7Cardiology Unit, IRCCS INRCA, Ancona, Italy.

Abstract

Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.

Keyword

Diabetes mellitus, type 2; Endothelium; Exercise; MicroRNAs; Oxidative stress

MeSH Terms

Adipose Tissue
Aryldialkylphosphatase
Biomarkers
Blood Pressure
Cardiovascular Diseases
Cause of Death
Diabetes Mellitus, Type 2
Down-Regulation
Endothelium
Exercise
Hemoglobin A, Glycosylated
Humans
MicroRNAs
Motor Activity
Oxidative Stress
Risk Factors*
Up-Regulation
Aryldialkylphosphatase
Biomarkers
MicroRNAs

Figure

  • Fig. 1 Relative expression (a.u.) of microRNA (miRNA)-21, -126, -130a, and -146a in low exercise (LE), medium exercise (ME), high exercise (HE) groups before (pre) and after (post) 3-month monitored exercise. aP<0.05 significant compared to study entry.


Cited by  1 articles

The Potential Role of MicroRNA in Diabetic Cardiomyopathy
Jin Hwa Kim
Diabetes Metab J. 2020;44(1):54-55.    doi: 10.4093/dmj.2020.0019.


Reference

1. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997; 275:964–967. PMID: 9020076.
Article
2. Leon BM, Maddox TM. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015; 6:1246–1258. PMID: 26468341.
Article
3. Green DJ, Maiorana A, O'Driscoll G, Taylor R. Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol. 2004; 561:1–25. PMID: 15375191.
Article
4. Gomez-Cabrera MC, Ferrando B, Brioche T, Sanchis-Gomar F, Vina J. Exercise and antioxidant supplements in the elderly. J Sport Health Sci. 2013; 2:94–100.
Article
5. McGinley SK, Armstrong MJ, Khandwala F, Zanuso S, Sigal RJ. Assessment of the MyWellness Key accelerometer in people with type 2 diabetes. Appl Physiol Nutr Metab. 2015; 40:1193–1198. PMID: 26489052.
Article
6. Sieverdes JC, Wickel EE, Hand GA, Bergamin M, Moran RR, Blair SN. Reliability and validity of the Mywellness Key physical activity monitor. Clin Epidemiol. 2013; 5:13–20. PMID: 23378783.
Article
7. Bergamin M, Ermolao A, Sieverdes JC, Zaccaria M, Zanuso S. Validation of the Mywellness Key in walking and running speeds. J Sports Sci Med. 2012; 11:57–63. PMID: 24149122.
8. Jette M, Sidney K, Blumchen G. Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity. Clin Cardiol. 1990; 13:555–565. PMID: 2204507.
Article
9. Mywellness. MyWellness Key. cited 2019 May 1. Available from: https://www.mywellness.com.
10. Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services: Physical Activity Guidelines Advisory Committee Report 2008. cited 2019 May 1. Available from: http://www.health.gov/PAGuidelines/Report.
11. Nichols WW, Singh BM. Augmentation index as a measure of peripheral vascular disease state. Curr Opin Cardiol. 2002; 17:543–551. PMID: 12357133.
Article
12. Orlando P, Silvestri S, Galeazzi R, Antonicelli R, Marcheggiani F, Cirilli I, Bacchetti T, Tiano L. Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes. Redox Rep. 2018; 23:136–145. PMID: 29734881.
Article
13. Olivieri F, Spazzafumo L, Bonafe M, Recchioni R, Prattichizzo F, Marcheselli F, Micolucci L, Mensa E, Giuliani A, Santini G, Gobbi M, Lazzarini R, Boemi M, Testa R, Antonicelli R, Procopio AD, Bonfigli AR. MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications. Oncotarget. 2015; 6:35372–35382. PMID: 26498351.
Article
14. Silvestri S, Orlando P, Armeni T, Padella L, Bruge F, Seddaiu G, Littarru GP, Tiano L. Coenzyme Q10 and α-lipoic acid: antioxidant and pro-oxidant effects in plasma and peripheral blood lymphocytes of supplemented subjects. J Clin Biochem Nutr. 2015; 57:21–26. PMID: 26236096.
15. Skarabahatava AS, Lukyanenko LM, Slobozhanina EI, Falcioni ML, Orlando P, Silvestri S, Tiano L, Falcioni G. Plasma and mitochondrial membrane perturbation induced by aluminum in human peripheral blood lymphocytes. J Trace Elem Med Biol. 2015; 31:37–44. PMID: 26004890.
Article
16. Kojda G, Hambrecht R. Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Cardiovasc Res. 2005; 67:187–197. PMID: 15935334.
Article
17. Olivieri F, Lazzarini R, Recchioni R, Marcheselli F, Rippo MR, Di Nuzzo S, Albertini MC, Graciotti L, Babini L, Mariotti S, Spada G, Abbatecola AM, Antonicelli R, Franceschi C, Procopio AD. MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr). 2013; 35:1157–1172. PMID: 22692818.
Article
18. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000; 321:405–412. PMID: 10938048.
Article
19. Meng S, Cao J, Zhang X, Fan Y, Fang L, Wang C, Lv Z, Fu D, Li Y. Downregulation of microRNA-130a contributes to endothelial progenitor cell dysfunction in diabetic patients via its target Runx3. PLoS One. 2013; 8:e68611. PMID: 23874686.
Article
20. Kelley GA, Kelley KS. Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials. Public Health. 2007; 121:643–655. PMID: 17544042.
Article
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