Ann Dermatol.  2017 Jun;29(3):337-340. 10.5021/ad.2017.29.3.337.

Interstitial Granulomatous Dermatitis in a Patient with Prostate Cancer

• Kim SM
• Cho SH
• Lee JD
• Kim HS

• KMID: 2378536
• DOI: http://doi.org/10.5021/ad.2017.29.3.337

Abstract

Interstitial granulomatous dermatitis (IGD) is a rare dermatosis, histologically characterized by an interstitial granulomatous infiltrate. It is associated with inflammatory arthritis, various medications, and autoimmune conditions. It is also associated with malignancies such as breast, endometrial, lung, and esophageal cancers as well as hematologic malignancies such as lymphoma and myelodysplastic syndrome. Herein we describe a case of IGD associated with prostate cancer, which has not been reported in the literature.

Keyword

Interstitial granulomatous dermatitis; Prostatic neoplasm

MeSH Terms

Arthritis
Breast
Dermatitis*
Esophageal Neoplasms
Hematologic Neoplasms
Humans
Immunoglobulin D
Lung
Lymphoma
Myelodysplastic Syndromes
Prostate*
Prostatic Neoplasms*
Skin Diseases
Immunoglobulin D

Figure

• 

  Fig. 1 (A) Multiple, irregularly-shaped, and erythematous to brown patches on the back. (B) Close-up view.

• 

  Fig. 2 Skin biopsy of the lesion revealing interstitial histiocytic infiltration throughout the dermis with few eosinophils and neutrophils (H&E; A: ×40, B: ×200). (C) Alcian blue at 2.5 pH revealed no mucin deposition in the interstitial infiltrate (×200).

Reference

1. Ackerman AB. Histologic diagnosis of inflammatory skin diseases: interstitial granulomatous dermatitis with arthritis. In : Ackerman AB, Guo Y, Vitale P, editors. Clues to diagnosis in dermatopathology. 1st ed. Chicago: ASCP Press;1993. p. 309–312.

2. Rosenbach M, English JC 3rd. Reactive granulomatous dermatitis: a review of palisaded neutrophilic and granulomatous dermatitis, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, and a proposed reclassification. Dermatol Clin. 2015; 33:373–387.

3. Peroni A, Colato C, Schena D, Gisondi P, Girolomoni G. Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. Br J Dermatol. 2012; 166:775–783.

4. Veronez IS, Dantas FL, Valente NY, Kakizaki P, Yasuda TH, Cunha Tdo A. Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis. An Bras Dermatol. 2015; 90:391–393.

5. Coutinho I, Pereira N, Gouveia M, Cardoso JC, Tellechea O. Interstitial granulomatous dermatitis: a clinicopathological study. Am J Dermatopathol. 2015; 37:614–619.

6. Thompson L, Abner S, Malone J, Callen JP. Interstitial granulomatous dermatitis as the initial manifestation of myeloma. JAMA Dermatol. 2015; 151:1141–1142.

7. Magro CM, Crowson AN, Schapiro BL. The interstitial granulomatous drug reaction: a distinctive clinical and pathological entity. J Cutan Pathol. 1998; 25:72–78.

8. Georgesen C, McDonough P, Cruz P. Interstitial granulomatous dermatitis associated with gabapentin. Dermatitis. 2014; 25:374–375.

9. Laura A, Luca P, Luisa PA. Interstitial granulomatous drug reaction due to febuxostat. Indian J Dermatol Venereol Leprol. 2014; 80:182–184.

10. Hernández N, Peñate Y, Borrego L. Generalized erythematous-violaceous plaques in a patient with a history of dyslipidemia. Interstitial granulomatous drug reaction (IGDR). Int J Dermatol. 2013; 52:393–394.

11. Schreckenberg C, Asch PH, Sibilia J, Walter S, Lipsker D, Heid E, et al. Interstitial granulomatous dermatitis and paraneoplastic rheumatoid polyarthritis disclosing cancer of the lung. Ann Dermatol Venereol. 1998; 125:585–588.

12. Moyano Almagro B, López Navarro N, Contreras Steyls M, Gallego Dominguez E, Herrera Acosta E, Herrera Ceballos E. Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. Clin Exp Dermatol. 2013; 38:501–503.