Infect Chemother.  2017 Mar;49(1):44-50. 10.3947/ic.2017.49.1.44.

Evaluation of Lipid Profile Changes in Pediatric Patients with Acute Mononucleosis

Affiliations
  • 1Department of Pediatrics, Division of Pediatric Infectious Diseases, Iran University of Medical sciences, Tehran, Iran. sayyahfar.sh@iums.ac.ir
  • 2Pediatrician, Bahman Hospital, Zanjan, Iran.
  • 3Pediatric Infections Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND
Acute Epstein-Barr virus (EBV) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with Infectious mononucleosis (IM). The aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery.
MATERIALS AND METHODS
From 2010 through 2012, 36 children with IM aged 1-10 years were enrolled in a prospective cross-sectional study. Fasting serum total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglyceride level were measured during acute phase of the disease and after 2 months of the recovery.
RESULTS
From 36 patients enrolled, 25 (69.4%) cases were male and the mean age of the patients was 4.1 ± 2.0 years. The mean of the total cholesterol level in the acute phase and 2 months after the recovery were149.5 ± 35.3 mg/dL and 145.7±30.6, respectively (P = 0.38). However, the serum level of HDL cholesterol in patients after 2 months of recovery was significantly increased (37.9 ± 9.3 mg/dL vs. 28.5 ± 10.6 mg/dL, P <0.001). The mean value of serum LDL cholesterol was significantly reduced, two months after recovery (81.4 ± 19.5 mg/dL, vs. 92.6 ± 28.8 mg/dL, P = 0.009). Furthermore, the serum triglyceride level was significantly reduced after the recovery (108.7 ± 36.9 mg/dL) compared with the acute phase (163.8 ± 114.3 mg/dL) (P = 0.004).
CONCLUSION
EBV infection in children could change lipid profile which is partially restored 2 months after the recovery.

Keyword

Atherogenic changes; Epstein–Barr virus; Infectious mononucleosis; Lipid profile; Pediatrics

MeSH Terms

Adult
Child
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Cross-Sectional Studies
Epstein-Barr Virus Infections
Fasting
Herpesvirus 4, Human
Humans
Infectious Mononucleosis
Lipoproteins
Male
Pediatrics
Prospective Studies
Triglycerides
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Lipoproteins

Figure

  • Figure 1 Distribution (mean and 95% confidence interval) of lipid profile in children with Epstein–Barr virus infection and relative atherogenesis risk categories in acute phase and two months after the recovery. TG, triglyceride; HDL, high-density lipoprotein; LDL; low-density lipoprotein; mo, month.

  • Figure 2 Correlation of lipid profile changes after two months of the recovery with acute phase values in patients with Epstein–Barr virus infection. (More negative changes for higher values of cholesterol, TG and LDL and more positive changes for lower values of HDL). TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein .


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