Pediatr Gastroenterol Hepatol Nutr.  2016 Dec;19(4):236-242. 10.5223/pghn.2016.19.4.236.

Clinical Features and Extraintestinal Manifestations of Crohn Disease in Children

Affiliations
  • 1Good Gang-An Hospital, Busan, Korea.
  • 2Department of Pediatrics, Pusan National University School of Medicine, Busan, Korea. jhongpark@pusan.ac.kr

Abstract

PURPOSE
The aim of this study was to investigate the clinical features and extraintestinal manifestations (EIMs) of Crohn disease (CD) in Korean pediatric patients.
METHODS
The medical records of 73 children diagnosed with CD were retrospectively reviewed. Data regarding baseline demographic and clinical characteristics, including CD phenotype at diagnosis based on the Montreal classification, and clinical features and course of EIMs were investigated.
RESULTS
Fifty-two (71.2%) of the patients were males. The mean age of the patients was 12.5 years. The mean follow-up period was 3.4 years. The disease location was ileal in 3 (4.1%) of the patients, colonic in 13 (17.8%), ileocolonic in 56 (76.7%). The clinical behavior was inflammatory in 62 (84.9%) of the patients, stricturing in 8 (11.0%), and penetrating in 3 (4.1%). Perianal abscesses or fistulas were found in 37 (50.7%) of the patients. EIMs observed during the study period were anal skin tag in 25 patients (34.2%), hypertransaminasemia in 20 (27.4%), peripheral arthritis in 2 (2.7%), erythema nodosum in 2 (2.7%), vulvitis in 1 (1.4%), uveitis in 1 (1.4%), and pulmonary thromboembolism in 1 (1.4%).
CONCLUSION
Perianal diseases and manifestations were present in more than half of Korean pediatric CD patients at diagnosis. Inspection of the anus should be mandatory in Korean children with suspicious CD, as perianal fistulas, abscesses, and anal skin tags may be the first clue to the diagnosis of CD.

Keyword

Crohn disease; Extraintestinal; Children

MeSH Terms

Abscess
Anal Canal
Arthritis
Child*
Classification
Colon
Crohn Disease*
Diagnosis
Erythema Nodosum
Fistula
Follow-Up Studies
Humans
Male
Medical Records
Phenotype
Pulmonary Embolism
Retrospective Studies
Skin
Uveitis
Vulvitis

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