J Korean Neuropsychiatr Assoc.  2003 May;42(3):302-313.

Pharmacotherapy and the Proposal of the Integrative Therapy Model for Treatment Resistant Obsessive-Compulsive Disorder

• Kwon JS
• Ha TH

Abstract

There have been considerable advances in our understanding of the neurobiology and the treatment of obsessive-compulsive disorder (OCD). However, it seems that many patients with OCD are not met with proper treatment, and even the patients who receive sufficient therapy the response rate is not high. This paper reviews the pharmacological treatments of OCD with special focus on therapeutic options for treatment resistance cases. In treating a resistant case, the clinical characteristics including comorbid conditions of the patient should be reevaluated. Through until recently, there has been no standarized guideline to treat resistance cases and much is up to clinician's preference, but thoughtful selection and combination of drugs with optimized psychosocial approach may improve the response rate. We propose an integrative therapy model for treatment resistant OCD to emphasize the need for the expansion of treatment resources. Treatment resistant OCD deserves more clinical and socioeconomic attentions and needs further research for management.

Keyword

Obsessive-Compulsive Disorder; Psychopharmacotherapy; Treatment resistance; Therapy model

MeSH Terms

Attention
Drug Therapy*
Humans
Neurobiology
Obsessive-Compulsive Disorder*