J Korean Neuropsychiatr Assoc.  2000 Jul;39(4):746-753.

HLA-DQA1, HLA-DQB1, and HLA-DRB1 Allele Frequency in Korean Patients with Schizophrenia

• Shin KS
• Lee MS
• Kim YR
• Kim YT
• Cho YJ

Abstract

OBJECTIVE
The aim of this study was to investigate the correlation between HLA-DQA1, HLA-DQB1 and HLA-DRB1 alleles and disease susceptibility in Korean schizophrenic patients.
METHODS
HLA-DQA1, HLA-DQB1, and HLA-DRB1 allele typing were performed using polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) method in 128 Korean schizophrenic patients diagnosed by DSM-IV criteria, who were not blood-related, and 160 normal blood bank donors.
RESULTS
The HLA-DQB1*04 allele frequency was 14.6% in schizophrenic patients, which was significantly higher than that of normal controls which was 8.2% (p=0.028). HLA-DRB1*14 allele frequency was 11.8% in patients, which was also more frequent than that of normal controls which was 5.5% (p=0.01). HLA-DRB*15 allele frequency was 2.0% in patients, which was significantly lower than that of normal controls which was 7.1% (p=0.007) and HLA-DRB*16 allele frequency was 1.6% in patients, which was also lower than that of normal controls which was 4.8% (p=0.043).
CONCLUSIONS
Schizophrenia in Korea had positive correlation with HLA-DQB1*04 and HLA-DRB1*14, and negative correlation with HLA-DRB1*15 and HLA-DRB1*16. These findings support the association of the HLA-DQB1 and HLA-DRB1 with schizophrenia in Korean population, which was different from other study results in other different ethnic groups.

Keyword

Schizophrenia; HLA; HLA-DRB1; HLA-DQA1; HLA-DQB1; Genetic polymorphism

MeSH Terms

Alleles*
Blood Banks
Diagnostic and Statistical Manual of Mental Disorders
Disease Susceptibility
Ethnic Groups
Gene Frequency*
HLA-DRB1 Chains*
Humans
Korea
Oligonucleotide Probes
Polymorphism, Genetic
Schizophrenia*
Tissue Donors
HLA-DRB1 Chains
Oligonucleotide Probes