J Korean Soc Pediatr Nephrol.  2009 Oct;13(2):146-152.

The Clinical Significance of Antiphospholipid Antibodies in Korean Children with Henoch-Schonlein Purpura

• Park EJ
• Baek JY
• Shin JI
• Lee JS
• Kim HS

Abstract

PURPOSE: We performed this study to evaluate the incidence and clinical significance of antiphospholipid antibodies (aPL Ab) in Korean children with Henoch-Schonlein purpura (HSP).
METHODS
The medical records of 62 patients (31 boys and 31 girls) aged 6.0+/-3.1 (1-16) years with a clinical diagnosis of HSP based on the EULAR/PReS criteria were reviewed retrospectively. From the years 2007 to 2009, the sera from children with acute HSP were tested for aPL Ab such as LA, anti-cardiolipin antibody and anti-beta2 glycoprotein I antibody.
RESULTS
LA was positive in 18 (29%) of the 62 patients with HSP and We divided the patients into the two groups LA positive group (N=18) and LA negative group (N=44). There were no significant differences between the two groups with regard to abdominal pain, arthralgia and renal involvement, but LA positive group had significantly higher C-reactive protein (4.3+/-7.2 mg/dL vs. 1.3+/-1.8 mg/dL, P=0.035), erythrocyte sedimentation rate (37.5+/-26.2 mm/hr vs. 25.1+/-22.6 mm/hr, P= 0.039), IgM (148.1+/-48.4 mg/dL vs. 114.9+/-41.5 mg/dL, P=0.024), C3 (143.1+/-21.9 mg/dL vs. 129.7+/-24.5 mg/dL, P=0.048) and C4 levels (30.9+/-6.3 mg/dL vs. 24.9+/-7.8 mg/dL, P=0.002) compared with LA negative group.
CONCLUSION
We found that the incidence of positive aPL Ab tests was relatively higher in Korean children with HSP and the presence of aPL Ab was associated with acute inflammatory process of HSP. These results suggest that the aPL Ab are involved in the pathogenesis of HSP in children.

Keyword

Henoch-Schonlein purpura; Antiphospholipid antibodies; Lupus anticoagulant

MeSH Terms

Abdominal Pain
Aged
Antibodies, Antiphospholipid
Arthralgia
Blood Sedimentation
C-Reactive Protein
Child
Glycoproteins
Humans
Immunoglobulin M
Incidence
Lupus Coagulation Inhibitor
Medical Records
Purpura, Schoenlein-Henoch
Retrospective Studies
Antibodies, Antiphospholipid
C-Reactive Protein
Glycoproteins
Immunoglobulin M
Lupus Coagulation Inhibitor