Korean J Dermatol.
1998 Oct;36(5):901-905.
Two Cases of Leukemia Cutis Showing Clinical Improvement with Systemic Retinoid Administration
Abstract
- Herein we report two cases of leukemia cutis that were responsive to oral all-tratm retinoic acid(ATRA) therapy. The two presented patients, who had been diagnosed with acute pmmyelocytic leukemia, disclosed specific lesions of leukemia cutis through histopathological examinations. Leukemia cutis due to acute promyelocytic leukemia is characterized by PML/RAR-a chimeric fusion proteins which arise from chromosomal trmslocation. This PML/RAR-a transcript can be a valuable molecular therapeutic target to systemic retinoid therapy in that ATRA induces terminal differentiation of leukemic clones and PML/RAR-a transcript preserves the ATRA-responsive signal transduction pathway. We concluded that leukemia cutis might be treated by tretinoin therapy without notifi.able adverse effects.
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