A study on the Relationship of the Severity of Psoriasis, Serum Soluble E-selectin, MCP-1 and RANTES

Park, Jung Hun; Kim, Nack In

Abstract

BACKGROUND
Psoriasis is a chronic skin disease characterized histologically by prominent keratinocyte hyperplasia and an early inflammatory cell infiltrate. However, the pathogenesis is not fully understood yet. Recently, the evidence that T lymphocytes play a key role in the pathogenesis of psoriasis is compelling. OBJECTIVE: The purpose of this study is to evaluate serum soluble E-selectin, MCP-1 and RANTES as severity indices or disease marker. In this study, we investigated a possible correlation between disease activity in psoriasis and serum soluble E-selectin, MCP-1 and RANTES, respectively. METHODS: Fifteen patients with psoriasis and fifteen normal controls were included in this study. The patients were evaluated for the symptoms and signs according to PASI score. We measured soluble E-selectin, MCP-1 and RANTES levels with blood samples drawn from patients and normal controls. RESULTS: 1. Soluble E-selectin serum levels were significantly increased in psoriatic patients compared with normal controls (p<0.05). Moreover, a significant correlation was demonstrated between serum soluble E-selectin values and PASI scores (r=0.54, p<0.05). 2. Serum MCP-1 levels were significantly increased in psoriatic patients compared with normal conrols (p<0.05). However, no significant correlation was observed between MCP-1 values and PASI scores (r=-0.12). 3. Serum RANTES levels were significantly increased in psoriatic patients compared with normal controls (p<0.05). Moreover, a positive correlation was observed between serum RANTES levels and PASI scores (r=0.63, p<0.05). CONCLUSION: These results suggest that serum levels of soluble E-selectin and RANTES could be used as marker of the disease activity in psoriatic patients.