Korean J Pediatr.
2009 Oct;52(10):1109-1118. 10.3345/kjp.2009.52.10.1109.
Metabolic syndrome in the overweight and obese adolescents and the impact of obesity on the cardiovascular system
- Affiliations
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- 1Department of Pediatrics, Ewha Womans University, Seoul, Korea. hongym@chollian.net
- 2Department of Pediatrics, College of Medicine, Inje University, Seoul, Korea.
- 3Department of Preventive Medicine, Ewha Womans University, Seoul, Korea.
- 4Department of Pediatric, Hong Ik Hospital, Seoul, Korea.
- 5Department of Pediatrics, College of Medicine, Ajou University, Suwon, Korea.
- 6Department of Pediatrics, College of Medicine, Han Yang University, Seoul, Korea.
- 7Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.
- KMID: 2281044
- DOI: http://doi.org/10.3345/kjp.2009.52.10.1109
Abstract
- PURPOSE
Metabolic syndrome (MS), characterized by obesity and insulin resistance, elicits risk factors such as hyperlipidemia, hypertension, and glucose intolerance with additive effects on atherosclerosis, leading to cardiovascular diseases. The purposes of this study were to evaluate the prevalence of MS among overweight and obese adolescents and to investigate the impact of obesity on the cardiovascular system.
METHODS
tal cholesterol, triglyceride, low-density-lipoprotein (LDL)-cholesterol, high-density-lipoprotein (HDL)-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and high-sensitive C-reactive protein (hs-CRP) were measured in the patients with a BMI of >85 percentile. Brachial-ankle pulse wave velocity (BaPWV) and ankle brachial index were measured using Vascular Profiler (VP)-1000.
RESULTS
MS was confirmed in 19.5% of the overweight and obese adolescents and 50.8% of the obese adolescents. The systolic and diastolic blood pressure, height, weight, fat mass, %fat, BMI, obesity index, and waist circumference were higher in the overweight and obese adolescents with MS. Moreover, the triglyceride, AST, ALT, and hs-CRP levels were higher, whereas HDL-cholesterol level was significantly lower in this group. The overweight and obese adolescents with MS showed shorter diastolic and systolic times, higher heart rate and BaPWV, and longer E-wave deceleration time by echocardiography.
CONCLUSION
Overweight and obese adolescents showed characteristic MS features such as hypertension and hyperlipidemia. Thus, obese adolescents predisposed to MS should be provided early treatment for obesity.
Keyword
MeSH Terms
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Adolescent
Alanine Transaminase
Ankle Brachial Index
Aspartate Aminotransferases
Atherosclerosis
Blood Pressure
C-Reactive Protein
Cardiovascular Diseases
Cardiovascular System
Cholesterol
Deceleration
Glucose Intolerance
Heart Diseases
Heart Rate
Humans
Hyperlipidemias
Hypertension
Insulin Resistance
Obesity
Overweight
Prevalence
Pulse Wave Analysis
Risk Factors
Waist Circumference
Alanine Transaminase
Aspartate Aminotransferases
C-Reactive Protein
Cholesterol
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