Korean J Med.
2003 Nov;65(Suppl 3):S867-S871.
A case of severe bleomycin-induced pulmonary fibrosis: reversal with high dose prednisolone
- Affiliations
-
- 1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. kimhj@mail.donga.ac.kr
- 2Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
Abstract
- We report the case that a 41-year-old male treated for testicular seminoma with combination chemotherapy that included bleomycin, developed life threatening pulmonary fibrosis. After orchiectomy, he completed four cycles of chemotherapy with bleomycin, etoposide, and cisplan. He developed a dry cough and progressive breathlessness and had bilateral fine inspiratory crackles on auscultation. Chest radiography showed bilateral interstitial infiltration and lung function tests confirmed a restrictive defect. Transbronchial biopsy specimens showed intersititial fibrosis. We thought that bleomycin lung toxicity was the likely diagnosis and he had clinical and radiographic improvement following prednisolone medication. This report suggests that bleomycin-induced pulmonary fibrosis may be reversible if treated aggressively. We report a case of bleomycin-induced pulmonary fibrosis with a review of the literature.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Effect of Steroid on the Bleomycin-Induced Pulmonary Fibrosis in Rat -Analysis of Cell Patterns in the Broncholaveolar Lavage Fluid, Histopathologic Findings and Total Collagen Content of the Lung-
- A Case of Bleomycin Induced Bronchiolitis Obliterans Orgnizing Pneumonia
- A Cse of Severe Bleomycin-Induved Pneumonitis at Non-Hodgkin's Lymphoma
- Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis
- A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals
