Korean J Hematol.  2010 Dec;45(4):215-216. 10.5045/kjh.2010.45.4.215.

Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) activation in acquired hemostatic dysfunction: a diagnostic challenge

• Kim HK

• KMID: 2252026
• DOI: http://doi.org/10.5045/kjh.2010.45.4.215

Abstract

No abstract available.

MeSH Terms

Carboxypeptidase U
Carboxypeptidase U

Reference

1. Bajzar L, Manuel R, Nesheim ME. Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. J Biol Chem. 1995; 270:14477–14484. PMID: 7782309.

2. Boffa MB, Koschinsky ML. Curiouser and curiouser: recent advances in measurement of thrombin-activatable fibrinolysis inhibitor (TAFI) and in understanding its molecular genetics, gene regulation, and biological roles. Clin Biochem. 2007; 40:431–442. PMID: 17331488.

3. Toh CH. Characterization of thrombin activatable fibrinolysis inhibitor in normal and acquired haemostatic dysfunction. Blood Coagul Fibrinolysis. 2003; 14(Suppl 1):S69–S71. PMID: 14567541.

4. Redlitz A, Nicolini FA, Malycky JL, Topol EJ, Plow EF. Inducible carboxypeptidase activity. A role in clot lysis in vivo. Circulation. 1996; 93:1328–1330. PMID: 8641019.

5. Heylen E, Miljic P, Willemse J, et al. Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophilia. Thromb Res. 2009; 124:427–432. PMID: 19195685.

6. Kraft P, Schwarz T, Meijers JC, Stoll G, Kleinschnitz C. Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice are susceptible to intracerebral thrombosis and ischemic stroke. PLoS One. 2010; 5:e11658. PMID: 20657835.

7. Renckens R, Roelofs JJ, ter Horst SA, et al. Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice. J Immunol. 2005; 175:6764–6771. PMID: 16272333.

8. Ceresa E, Brouwers E, Peeters M, Jern C, Declerck PJ, Gils A. Development of ELISAs measuring the extent of TAFI activation. Arterioscler Thromb Vasc Biol. 2006; 26:423–428. PMID: 16339503.

9. Park R, Song J, An SS. Elevated TAFIa/ai levels in patient with sepsis and normal controls with TAFIa/ai specific ELISA. Korean J Hematol. 2010; 45:264–268.

10. Emonts M, de Bruijne EL, Guimarães AH, et al. Thrombin-activatable fibrinolysis inhibitor is associated with severity and outcome of severe meningococcal infection in children. J Thromb Haemost. 2008; 6:268–276. PMID: 18021301.