J Korean Ophthalmol Soc.  2015 Jan;56(1):114-118. 10.3341/jkos.2015.56.1.114.

A Case of Granular Cell Tumor of the Orbit

• Kim Y
• Lee SJ
• Oh MJ

• KMID: 2216163
• DOI: http://doi.org/10.3341/jkos.2015.56.1.114

Abstract

PURPOSE
To report a case of granular cell tumor of the orbit in a patient, complaining of foreign body sensation due to entropion.
CASE SUMMARY
A 59-year-old man visited our clinic because of foreign body sensation in the right eye due to entropion. A white mass was noted at the right palpebral conjunctiva, and bulbar conjunctiva chemosis was seen. We performed excisional biopsy and capsulopalpebral fascia repair for lower lid entropion. Histopathological examination revealed a granular cell tumor. There were no complications after surgery.
CONCLUSIONS
Granular cell tumor of the orbit is rare, but it should be considered in the differential diagnosis of a mass lesion causing entropion or diplopia.

Keyword

Granular cell tumor; Orbital tumor

MeSH Terms

Biopsy
Conjunctiva
Diagnosis, Differential
Diplopia
Entropion
Fascia
Foreign Bodies
Granular Cell Tumor*
Humans
Middle Aged
Orbit*
Sensation

Figure

• 

  Figure 1. Photographs taken in the nine cardinal directions at the first visit are showing mild limitation of depression of the right eye.

• 

  Figure 2. Axial (left) and coronal (right) orbital CT scans with contrast enhancement demonstrated a welldefined 0.6 × 1.3 × 1.4 cmsized mass of the right inferolateral orbit (white arrow).

• 

  Figure 3. Results of Hematoxylin-Eosin staining (H-E) and im-munohistochemical staining. (A) The tumor consists of granular cytoplasmic cells (H-E, ×400) which were positively stained at (B) periodic acid-Schiff, (C) S-100 protein, (D) CD68, and (E) neuron specific enolase (×400).

Reference

References

1. Jaeger MJ, Green WR, Miller NR, Harris GJ. Granular cell tumor of the orbit and ocular adnexae. Surv Ophthalmol. 1987; 31:417–23.

2. Ordóñez NG, Mackay B. Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol. 1999; 23:207–22.

3. Ahn JH, Seo SG, Her J. A case of granular cell tumor in form of ciliary body tumor. J Korean Ophthalmol Soc. 2009; 50:790–3.

4. Park YH, Park BG. A case of granular cell myoblastoma of the orbit. J Korean Ophthalmol Soc. 1987; 28:1395–9.

5. Yoo KW, Yoo GH, Cho KR. Infiltrating orbital granular cell tumor: A case report. J Korean Ophthalmol Soc. 1990; 31:87–91.

6. Abrikossoff A. Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch Pathol Anat Physiol Klin Med. 1926; 260:215–33.

7. Ribeiro SF, Chahud F, Cruz AA. Oculomotor disturbances due to granular cell tumor. Ophthal Plast Reconstr Surg. 2012; 28:e23–7.

8. Stewart F, Frierson H, Levin P. . Textbook of uncommon cancer. Sussex, England: John Wiley & Sons;1988. p. 669–82.

9. Garrity JA, Henderson JW, Cameron JD. Henderson's orbital tumors. 4th ed.Philadelphia: Lippincott Williams & Wilkins;2007. p. 175–7.

10. Noonan JD, Horton CE, Old WL, Stokes TL. Granular cell myoblastoma of the head and neck: review of the literature and 10 year experience. Am J Surg. 1979; 138:611–4.

11. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998; 22:779–94.

12. Callejo SA, Kronish JW, Decker SJ. . Malignant granular cell tumor metastatic to the orbit. Ophthalmology. 2000; 107:550–4.

13. Fernandes BF, Belfort Neto R, Odashiro AN. . Clinical and his-topathological features of orbital granular cell tumor: case report. Arq Bras Oftalmol. 2012; 75:137–9.