J Korean Ophthalmol Soc.  2010 Feb;51(2):220-226. 10.3341/jkos.2010.51.2.220.

Comparison of Total Deviation of Standard Automated Perimetry and Matrix FDT in Preperimetric Glaucoma Patients

• Choi JH
• Park IW
• Chung YS

• KMID: 2213143
• DOI: http://doi.org/10.3341/jkos.2010.51.2.220

Abstract

PURPOSE
To compare the results of total deviation (TD) as measured by standard automated perimetry (SAP) and measured with of Matrix Frequency-doubling Technology (FDT) in patients with preperimetric glaucoma.
METHODS
Fifty-two eyes of 52 patients with preperimetric glaucoma were included. Subjects were examined with Matrix FDT and Stratus optical coherence tomography (OCT), and the results of each examination were analyzed. The proportions of abnormal results in SAP TD, Matrix TD, and Matrix pattern deviation (PD) were calculated. Among the results of tests, the following correlations were evaluated: SAP TD and Matrix, and visual fields and OCT. In addition, the differences in peripapillary retinal nerve fiber layer thickness (RNFL) according to the result of SAP TD in preperimetric patients with abnormal Matrix PD were analyzed.
RESULTS
A abnormalities in SAP TD, Matrix TD and Matrix PD were found in 22 (42.3%), 34 (65.4%), 41 (78.9%) eyes, respectively. There was marginal correlation between SAP TD and Matrix PD (p=0.07). No significant correlation was found between SAP TD and OCT, although Matrix PD and OCT did show significant correlation (p<0.05). In preperimetric patients with abnormal Matrix PD, RNFL thickness was significantly lower in the abnormal SAP TD group than in the normal SAP TD group on average, in the superior quadrant, and at the 12 o'clock and 5 o'clock positions (p<0.05).
CONCLUSIONS
In patients with preperimetric glaucoma, 42.3% and 78.9% had glaucomatous VF defects in SAP TD and Matrix PD, respectively. These results were higher than expected, especially those of SAP TD.

Keyword

Matrix frequency-doubling technology; Optical coherence tomography; Preperimetric glaucoma; Standard automated perimetry; Total deviation

MeSH Terms

Eye
Glaucoma
Humans
Nerve Fibers
Retinaldehyde
Tomography, Optical Coherence
Visual Field Tests
Visual Fields
Retinaldehyde

Figure

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  Figure 1. Abnormalities among SAP TD, Matrix TD and Matrix PD were found in 22 (42.3%), 34 (65.4%), 41 (78.9%) eyes, respectively. SAP=standard automated perimetry; Matrix=Matrix FDT; TD=total deviation; PD=pattern deviation.

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  Figure 2. Comparison of RNFL thickness (μm) of Straus OCT clock-hours according to the result of SAP TD show RNFL thickness was significantly lower in abnormal SAP TD group(*) than normal SAP TD group(+) at 12 o'clock, and 5 o'clock (p<0.05).

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  Figure 3. A 41-year-old patient with preperimetric glaucoma. (A) Disc and red-free photographs show glaucomatous cupping and localized retinal nerve fiber layer (RNFL) defect. (B) Result of Humphrey visual field is normal according to the Anderson criteria but total deviation plot shows abnormal result. (C) Stratus OCT shows RNFL thinning at the inferior temporal region.

Reference

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