J Korean Rheum Assoc.  2010 Jun;17(2):133-142. 10.4078/jkra.2010.17.2.133.

Clinical Manifestations of Korean Adult Patients with Henoch-Schonlein Purpura

• Kang Y
• Ha YJ
• Lee KH
• Jung SY
• Lee SW
• Lee SK
• Park YB

• KMID: 2201955
• DOI: http://doi.org/10.4078/jkra.2010.17.2.133

Abstract

OBJECTIVE
We investigated the clinical data and analyzed the significant prognostic factors for outcomes in Korean adult patients with Henoch-Schonlein Purpura (HSP).
METHODS
We retrospectively reviewed the medical records of 52 patients over 20 years-old, who visited the Yonsei University Severance Hospital from December 1999 to November 2009, and fulfilled the classification criteria for HSP. We investigated the epidemiologic data, clinical features, renal biopsy findings, laboratory results and disease outcomes.
RESULTS
The median age was 43.5 (20~83) years old and 29 out of 52 patients (55.8%) were male. HSP exhibited seasonal variation and most frequently developed in winter (42.3%), followed by spring (25.0%). Upper respiratory infection was the most common known preceding event for HSP development. Skin manifestations were observed in all subjects, followed by kidney (80.8%), gastro-intestine (57.7%) and joints (26.9%). After a median follow-up period 14.5 (1~227) months, 12 patients experienced HSP relapse (23.1%), and 7 patients had chronic renal failure (13.4%). Univariate analysis showed that renal insufficiency (p=0.002) and nephritic syndrome (p=0.026) at diagnosis were significantly related to the development of chronic renal failure. Of the two parameters, only initial renal insufficiency was found to be a significant predictive value for chronic renal failure (OR=28.7, p=0.001, 95% confidential interval 3.6~225.3).
CONCLUSION
Renal insufficiency at diagnosis may be a useful predictive factor for progression to chronic renal failure in Korean adult patients with HSP.

Keyword

Henoch-Schonlein Purpura; Adult; Clinical manifestation; Prognosis; Chronic renal failure

MeSH Terms

Adult
Biopsy
Follow-Up Studies
Humans
Joints
Kidney
Kidney Failure, Chronic
Male
Medical Records
Prognosis
Purpura, Schoenlein-Henoch
Recurrence
Renal Insufficiency
Retrospective Studies
Seasons
Skin Manifestations

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