1. Jones GT, Atzeni F, Beasley M, Flüβ E, Sarzi-Puttini P, Macfarlane GJ. The prevalence of fibromyalgia in the general population: a comparison of the American College of Rheumatology 1990, 2010, and modified 2010 classification criteria. Arthritis Rheumatol. 2015; 67:568–575. PMID:
25323744.
2. Bennett RM, Friend R, Jones KD, Ward R, Han BK, Ross RL. The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties. Arthritis Res Ther. 2009; 11:R120. PMID:
19664287.
3. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010; 62:600–610. PMID:
20461783.
4. Kim SK, Kim SH, Lee CK, Lee HS, Lee SH, Park YB, et al. Effect of fibromyalgia syndrome on the health-related quality of life and economic burden in Korea. Rheumatology (Oxford). 2013; 52:311–320. PMID:
23024016.
5. Doron Y, Peleg R, Peleg A, Neumann L, Buskila D. The clinical and economic burden of fibromyalgia compared with diabetes mellitus and hypertension among Bedouin women in the Negev. Fam Pract. 2004; 21:415–419. PMID:
15249530.
6. Maletic V, Raison CL. Neurobiology of depression, fibromyalgia and neuropathic pain. Front Biosci (Landmark Ed). 2009; 14:5291–5338. PMID:
19482616.
7. Sommer C, Häuser W, Burgmer M, Engelhardt R, Gerhold K, Petzke F, et al. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften. Etiology and pathophysiology of fibromyalgia syndrome. Schmerz. 2012; 26:259–267. PMID:
22760458.
8. Ablin J, Neumann L, Buskila D. Pathogenesis of fibromyalgia -a review. Joint Bone Spine. 2008; 75:273–279. PMID:
18375167.
9. Buskila D, Sarzi-Puttini P. Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther. 2006; 8:218. PMID:
16887010.
10. Vargas-Alarcon G, Alvarez-Leon E, Fragoso JM, Vargas A, Martinez A, Vallejo M, et al. A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia. BMC Musculoskelet Disord. 2012; 13:23. PMID:
22348792.
11. Mogil JS. Pain genetics: past, present and future. Trends Genet. 2012; 28:258–266. PMID:
22464640.
12. Altman D, Lundholm C, Milsom I, Peeker R, Fall M, Iliadou AN, et al. The genetic and environmental contribution to the occurrence of bladder pain syndrome: an empirical approach in a nationwide population sample. Eur Urol. 2011; 59:280–285. PMID:
21056533.
13. Peters MJ, Broer L, Willemen HL, Eiriksdottir G, Hocking LJ, Holliday KL, et al. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. Ann Rheum Dis. 2013; 72:427–436. PMID:
22956598.
14. Wang W, Gu J, Li YQ, Tao YX. Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain? Mol Pain. 2011; 7:16. PMID:
21345196.
15. Ichinose H, Suzuki T, Inagaki H, Ohye T, Nagatsu T. Molecular genetics of dopa-responsive dystonia. Biol Chem. 1999; 380:1355–1364. PMID:
10661862.
16. Oertel B, Lötsch J. Genetic mutations that prevent pain: implications for future pain medication. Pharmacogenomics. 2008; 9:179–194. PMID:
18370847.
17. Martínez-Jauand M, Sitges C, Rodríguez V, Picornell A, Ramon M, Buskila D, et al. Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene. Eur J Pain. 2013; 17:16–27. PMID:
22528689.
18. Pellegrino MJ, Waylonis GW, Sommer A. Familial occurrence of primary fibromyalgia. Arch Phys Med Rehabil. 1989; 70:61–63. PMID:
2916922.
19. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990; 33:160–172. PMID:
2306288.
20. Buskila D, Neumann L, Hazanov I, Carmi R. Familial aggregation in the fibromyalgia syndrome. Semin Arthritis Rheum. 1996; 26:605–611. PMID:
8989805.
21. Buskila D, Neumann L. Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. J Rheumatol. 1997; 24:941–944. PMID:
9150086.
22. Arnold LM, Hudson JI, Hess EV, Ware AE, Fritz DA, Auchenbach MB, et al. Family study of fibromyalgia. Arthritis Rheum. 2004; 50:944–952. PMID:
15022338.
23. Fitzcharles MA, Rampakakis E, Ste-Marie PA, Sampalis JS, Shir Y. The association of socioeconomic status and symptom severity in persons with fibromyalgia. J Rheumatol. 2014; 41:1398–1404. PMID:
24931954.
24. Assumpção A, Cavalcante AB, Capela CE, Sauer JF, Chalot SD, Pereira CA, et al. Prevalence of fibromyalgia in a low socioeconomic status population. BMC Musculoskelet Disord. 2009; 10:64. PMID:
19505321.
25. Cohen H, Buskila D, Neumann L, Ebstein RP. Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum. 2002; 46:845–847. PMID:
11920428.
26. Buskila D, Cohen H, Neumann L, Ebstein RP. An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. Mol Psychiatry. 2004; 9:730–731. PMID:
15052273.
27. Gürsoy S, Erdal E, Herken H, Madenci E, Alaşehirli B. Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fibromyalgia syndrome. Rheumatol Int. 2001; 21:58–61. PMID:
11732859.
28. Finan PH, Zautra AJ, Davis MC, Lemery-Chalfant K, Covault J, Tennen H. COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. Pain. 2011; 152:300–307. PMID:
21130573.
29. Norrgard K. Genetic variation and disease: GWAS. Nat Educ. 2008; 1:87.
30. Landstrom AP, Ackerman MJ. GWAS or Gee Whiz, PSAS or Pshaw: elucidating the biologic and clinical significance of genetic variation in cardiovascular disease. Heart Rhythm. 2009; 6:1751–1753. PMID:
19959124.
31. Dawn Teare M, Barrett JH. Genetic linkage studies. Lancet. 2005; 366:1036–1044. PMID:
16168786.
32. Docampo E, Escaramís G, Gratacòs M, Villatoro S, Puig A, Kogevinas M, et al. Genome-wide analysis of single nucleotide polymorphisms and copy number variants in fibromyalgia suggest a role for the central nervous system. Pain. 2014; 155:1102–1109. PMID:
24582949.
33. Feng J, Zhang Z, Wu X, Mao A, Chang F, Deng X, et al. Discovery of potential new gene variants and inflammatory cytokine associations with fibromyalgia syndrome by whole exome sequencing. PLoS One. 2013; 8:e65033. PMID:
23762283.
34. Arnold LM, Fan J, Russell IJ, Yunus MB, Khan MA, Kushner I, et al. The fibromyalgia family study: a genome-wide linkage scan study. Arthritis Rheum. 2013; 65:1122–1128. PMID:
23280346.
35. Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Javors MA, Bowden CA. Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol. 1992; 19:104–109. PMID:
1313504.
36. Russell IJ, Vaeroy H, Javors M, Nyberg F. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis Rheum. 1992; 35:550–556. PMID:
1374252.
37. Wolfe F, Russell IJ, Vipraio G, Ross K, Anderson J. Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol. 1997; 24:555–559. PMID:
9058665.
38. Kuzelova H, Ptacek R, Macek M. The serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literature. Neuro Endocrinol Lett. 2010; 31:4–10. PMID:
20150867.
39. Bondy B, Spaeth M, Offenbaecher M, Glatzeder K, Stratz T, Schwarz M, et al. The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis. 1999; 6:433–439. PMID:
10527809.
40. Lee YH, Choi SJ, Ji JD, Song GG. Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int. 2012; 32:417–426. PMID:
21120487.
41. Offenbaecher M, Bondy B, de Jonge S, Glatzeder K, Krüger M, Schoeps P, et al. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum. 1999; 42:2482–2488. PMID:
10555044.
42. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996; 274:1527–1531. PMID:
8929413.
43. Gursoy S. Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients. Clin Rheumatol. 2002; 21:194–197. PMID:
12111622.
44. Frank B, Niesler B, Bondy B, Späth M, Pongratz DE, Ackenheil M, et al. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. Clin Rheumatol. 2004; 23:338–344. PMID:
15293096.
45. Hrycaj P, Stratz T, Mennet P, Müller W. Pathogenetic aspects of responsiveness to ondansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome--a preliminary study. J Rheumatol. 1996; 23:1418–1423. PMID:
8856622.
46. Haus U, Varga B, Stratz T, Späth M, Müller W. Oral treatment of fibromyalgia with tropisetron given over 28 days: influence on functional and vegetative symptoms, psychometric parameters and pain. Scand J Rheumatol Suppl. 2000; 113:55–58. PMID:
11028833.
47. Ernberg M, Lundeberg T, Kopp S. Effects on muscle pain by intramuscular injection of granisetron in patients with fibromyalgia. Pain. 2003; 101:275–282. PMID:
12583870.
48. Murphy DL, Andrews AM, Wichems CH, Li Q, Tohda M, Greenberg B. Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J Clin Psychiatry. 1998; 59(Suppl 15):4–12. PMID:
9786305.
49. Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009; 10:895–926. PMID:
19712899.
50. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011; 152(3 Suppl):S2–S15. PMID:
20961685.
51. Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, et al. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science. 2003; 299:1240–1243. PMID:
12595695.
52. Männistö PT, Kaakkola S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev. 1999; 51:593–628. PMID:
10581325.
53. Matsuda JB, Barbosa FR, Morel LJ, França Sde C, Zingaretti SM, da Silva LM, et al. Serotonin receptor (5-HT 2A) and catechol-O-methyltransferase (COMT) gene polymorphisms: triggers of fibromyalgia? Rev Bras Reumatol. 2010; 50:141–149. PMID:
21125150.
54. Gürsoy S, Erdal E, Herken H, Madenci E, Alaşehirli B, Erdal N. Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int. 2003; 23:104–107. PMID:
12739038.
55. Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Vargas A, Lao-Villadóniga JI, et al. Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Arthritis Res Ther. 2007; 9:R110. PMID:
17961261.
56. Cohen H, Neumann L, Glazer Y, Ebstein RP, Buskila D. The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. Clin Exp Rheumatol. 2009; 27(5 Suppl 56):S51–S56. PMID:
20074440.
57. Barbosa FR, Matsuda JB, Mazucato M, de Castro França S, Zingaretti SM, da Silva LM, et al. Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients. Rheumatol Int. 2012; 32:427–430. PMID:
21120493.
58. Potvin S, Larouche A, Normand E, de Souza JB, Gaumond I, Grignon S, et al. DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls. J Pain. 2009; 10:969–975. PMID:
19464960.
59. Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, et al. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int. 2008; 28:685–691. PMID:
18196244.
60. Lee YH, Kim JH, Song GG. Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis. Rheumatol Int. 2015; 35:159–166. PMID:
24951880.
61. International HapMap Consortium. A haplotype map of the human genome. Nature. 2005; 437:1299–1320. PMID:
16255080.
62. Diatchenko L, Nackley AG, Slade GD, Bhalang K, Belfer I, Max MB, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain. 2006; 125:216–224. PMID:
16837133.
63. Jarcho JM, Mayer EA, Jiang ZK, Feier NA, London ED. Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction. Pain. 2012; 153:744–754. PMID:
22386471.
64. Wood PB. Role of central dopamine in pain and analgesia. Expert Rev Neurother. 2008; 8:781–797. PMID:
18457535.
65. Malt EA, Olafsson S, Aakvaag A, Lund A, Ursin H. Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. J Affect Disord. 2003; 75:77–82. PMID:
12781354.
66. Wood PB, Schweinhardt P, Jaeger E, Dagher A, Hakyemez H, Rabiner EA, et al. Fibromyalgia patients show an abnormal dopamine response to pain. Eur J Neurosci. 2007; 25:3576–3582. PMID:
17610577.
67. Holman AJ, Myers RR. A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications. Arthritis Rheum. 2005; 52:2495–2505. PMID:
16052595.
68. Eglen RM, Hunter JC, Dray A. Ions in the fire: recent ion-channel research and approaches to pain therapy. Trends Pharmacol Sci. 1999; 20:337–342. PMID:
10431213.
69. Kim SK, Kim SH, Nah SS, Lee JH, Hong SJ, Kim HS, et al. Association of guanosine triphosphate cyclohydrolase 1 gene polymorphisms with fibromyalgia syndrome in a Korean population. J Rheumatol. 2013; 40:316–322. PMID:
23322459.
70. Kingwell BA. Nitric oxide-mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease. FASEB J. 2000; 14:1685–1696. PMID:
10973917.
71. Larson AA, Giovengo SL, Russell IJ, Michalek JE. Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways. Pain. 2000; 87:201–211. PMID:
10924813.
72. Martinez-Lavin M. Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia. Arthritis Res Ther. 2007; 9:216. PMID:
17626613.
73. Small KM, McGraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol. 2003; 43:381–411. PMID:
12540746.
74. Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Martinez A, Lao-Villadóniga JI, et al. Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains. Arthritis Rheum. 2009; 60:2169–2173. PMID:
19565482.