Ewha Med J.  2014 Mar;37(1):16-25. 10.12771/emj.2014.37.1.16.

Renal Cell Neoplasms: Recent Advances

• Park S
• Ro JY

• KMID: 2171269
• DOI: http://doi.org/10.12771/emj.2014.37.1.16

Abstract

The incidence of renal cell neoplasms has been increased in worldwide as well as in Korea. Even though the World Health Organization (WHO) Classification of renal tumors (2004) is currently used, new entities require to be added in the updated classification because of recent modification with our understanding of the molecular biology and different clinical behavior of new renal tumors. In this review, recently described tumors and candidate entities will be discussed. It is of importance to know these new entities for the proper diagnosis, treatment, and their prognosis.

Keyword

Renal cell carcinoma; Classification

MeSH Terms

Carcinoma, Renal Cell
Classification
Diagnosis
Incidence
Korea
Molecular Biology
Prognosis
World Health Organization

Figure

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  Fig. 1 Tubulocystic renal cell carcinoma. Various sized micro-and macrocysts lined by one-cell are layered hobnailed cuboidal cells (H&E, 200).

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  Fig. 2 Thyroid-like follicular carcinoma of kidney. Thyroid-like microfollicles are filled with colloid-like material (H&E, 200).

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  Fig. 3 Acquired cystic kidney disease-associated renal cell carcinoma. Tubules lined by multilayered atypical epithelial cells with prominent vacuolization and oxalate crystals (Courtesy of Dr. Cho, Asan Medical Center, Seoul, Korea) (H&E, 200).

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  Fig. 4 Clear cell papillary renal cell carcinoma. Bland-looking tubules are lined by clear cells with low Fuhrman nuclear grade in a linear arrangement of nuclei away from the basement membrane (H&E, 100).

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  Fig. 5 Renal cell carcinoma with t(6;11) translocation. Distinctive biphasic larger and smaller epithelioid tumor cells, with the smaller cells being clustered around eosinophilic basement membrane-like material and larger cells have clear to light eosinophilic abundant cytoplasm (courtesy of Drs. Smith and Amin, Cedars-Sinai Medical Center, LA, CA, USA) (H&E, 200).

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  Fig. 6 Hybrid oncocytoma/chromophobe renal cell carcinoma (RCC). Solid growth pattern with combined oncocytoma cells (left) and chromophobe RCC tumor cells with distinct cell borders and perinuclear halo (right) are present (H&E, 200).

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  Fig. 7 Hereditary leiomyomatosis and renal cell carcinoma syndrome. Large papillary-alveolar structures are lined by eosinophilic cells with enlarged nuclei and prominent inclusion-like nucleoli (Courtesy of Drs. Smith and Amin, Cedars-Sinai Medical Center, LA, CA, USA) (H&E, 200).

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  Fig. 8 Renal angiomyoadenomatous tumor. Nests of tumor cells with clear to eosinophilic cytoplasm are surrounded by abundant leiomyomatous stroma and the tumor cells occasionally protrude into the lumen, resembling a so-called "shark's smile" (arrow) (H&E, 200).

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