Hanyang Med Rev.  2016 Feb;36(1):46-54. 10.7599/hmr.2016.36.1.46.

Tic & Tourette Syndrome and Motor Disorders

• Park TW
• Park J

• KMID: 2168371
• DOI: http://doi.org/10.7599/hmr.2016.36.1.46

Abstract

Motor disorders in childhood include tic disorder, developmental coordination disorder, and stereotypic movement disorder. A tic is a sudden, rapid, repetitive and nonrhythmic movement (motor tics) or phonic production (phonic or vocal tics) that can occur at any part of the body. Developmental coordination disorder (DCD) is characterized by marked impairment in the acquisition and performance of motor skills. Stereotypic movement disorder is a common childhood disorder which repetitive, hard to control, aimless motor activity interrupts everyday life or causes self-infliction of a child. Despite increased attention and the growing scientific knowledge about motor disorders, there are limitations in our understanding and knowledge about the pathogenesis and the management of the disorders. Motor disorders can itself be the primary diagnosis, or can be secondarily diagnosed caused by other disorders, and accompany many neuropsychiatric disorders such as autism and attention deficit hyperactivity disorder (ADHD), which in turn impairs proper learning and socializing of the children with motor disorders. Therefore comprehensive medical history taking, continuous observation of the changes in symptoms, and systematic assessment considering the child's developmental stage and current adaptive capacity are needed. Behavioral therapy and pharmacological therapy are the two most often mentioned treatments of motor disorders.

Keyword

Child; Adolescent; Tic Disorders; Motor Skills Disorders; Stereotypic Movement Disorder

MeSH Terms

Adolescent
Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Child
Diagnosis
Humans
Learning
Medical History Taking
Motor Activity
Motor Skills
Motor Skills Disorders
Stereotypic Movement Disorder
Tic Disorders
Tics*
Tourette Syndrome*

Reference

1. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 5th Ed. Washington DC: American Psychiatric Association;2013.

2. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 3rd Ed. Washington DC: American Psychiatric Association;1980.

3. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 4th Ed. Washington DC: American Psychiatric Association;1994.

4. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 4th Ed. Washington DC: American Psychiatric Association;2000. Text Revision.

5. Robertson MM. The prevalence and epidemiology of Gilles de la Tourette syndrome part 1: the epidemiological and prevalence studies. J Psychosom Res. 2008; 65:461–472.

6. Centers for Disease Control and Prevention (CDC). Prevalence of diagnosed Tourette syndrome in persons aged 6-17 years—United States, 2007. MMWR Morb Mortal Wkly Rep. 2009; 58:581–585.

7. Kurlan R, McDermott MP, Deeley C, Como PG, Brower C, Eapen S, et al. Prevalence of tics in schoolchildren and association with placement in special education. Neurology. 2001; 57:1383–1388.

8. Price RA, Kidd KK, Cohen DJ, Pauls DL, Leckman JF. A twin study of Tourette syndrome. Arch Gen Psychiatry. 1985; 42:815–820.

9. Hanna PA, Janjua FN, Contant CF, Jankovic J. Bilineal transmission in Tourette syndrome. Neurology. 1999; 53:813–818.

10. Lichter DG, Dmochowski J, Jackson LA, Trinidad KS. Influence of family history on clinical expression of Tourette's syndrome. Neurology. 1999; 52:308–316.

11. Leckman JF. Tourette's syndrome. Lancet. 2002; 360:1577–1586.

12. Bloch M, State M, Pittenger C. Recent advances in Tourette syndrome. Curr Opin Neurol. 2011; 24:119–125.

13. Rothenberger A, Roessner V. Functional neuroimaging investigations of motor networks in Tourette syndrome. Behav Neurol. 2013; 27:47–55.

14. Leckman JF, Vaccarino FM, Kalanithi PS, Rothenberger A. Annotation: Tourette syndrome: a relentless drumbeat—driven by misguided brain oscillations. J Child Psychol Psychiatry. 2006; 47:537–550.

15. Felling RJ, Singer HS. Neurobiology of Tourette syndrome: current status and need for further investigation. J Neurosci. 2011; 31:12387–12395.

16. Jankovic J, Kurlan R. Tourette syndrome: evolving concepts. Mov Disord. 2011; 26:1149–1156.

17. Singer HS, Hahn IH, Moran TH. Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome. Ann Neurol. 1991; 30:558–562.

18. Fredericksen KA, Cutting LE, Kates WR, Mostofsky SH, Singer HS, Cooper KL, et al. Disproportionate increases of white matter in right frontal lobe in Tourette syndrome. Neurology. 2002; 58:85–89.

19. Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, et al. Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome. Arch Pediatr Adolesc Med. 2006; 160:65–69.

20. Leckman JF, Peterson BS, King RA, Scahill L, Cohen DJ. Phenomenology of tics and natural history of tic disorders. Adv Neurol. 2001; 85:1–14.

21. Coffey BJ, Biederman J, Geller DA, Spencer T, Park KS, Shapiro SJ, et al. The course of Tourette's disorder: a literature review. Harv Rev Psychiatry. 2000; 8:192–198.

22. Freeman RD, Zinner SH, Müller-Vahl KR, Fast DK, Burd LJ, Kano Y, et al. Coprophenomena in Tourette syndrome. Dev Med Child Neurol. 2009; 51:218–227.

23. Leckman JF, Bloch MH, Scahill L, King RA. Tourette syndrome: the self under siege. J Child Neurol. 2006; 21:642–649.

24. Leckman JF, Walker DE, Cohen DJ. Premonitory urges in Tourette's syndrome. Am J Psychiatry. 1993; 150:98–102.

25. Jankovic J. Tourette's syndrome. N Engl J Med. 2001; 345:1184–1192.

26. Miguel EC, Coffey BJ, Baer L, Savage CR, Rauch SL, Jenike MA. Phenomenology of intentional repetitive behaviors in obsessive-compulsive disorder and Tourette's disorder. J Clin Psychiatry. 1995; 56:246–255.

27. Robertson MM. Tourette syndrome, associated conditions and the complexities of treatment. Brain. 2000; 123:425–462.

28. Leckman JF, Pauls DL, Zhang H, Rosario-Campos MC, Katsovich L, Kidd KK, et al. Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome. Am J Med Genet B Neuropsychiatr Genet. 2003; 116B:60–68.

29. Gaze C, Kepley HO, Walkup JT. Co-occurring psychiatric disorders in children and adolescents with Tourette syndrome. J Child Neurol. 2006; 21:657–664.

30. Peterson BS, Cohen DJ. The treatment of Tourette's syndrome: multimodal, developmental intervention. J Clin Psychiatry. 1998; 59:Suppl 1. 62–72. discussion 73-4

31. Shprecher D, Kurlan R. The management of tics. Mov Disord. 2009; 24:15–24.

32. Jankovic J. Treatment of hyperkinetic movement disorders. Lancet Neurol. 2009; 8:844–856.

33. Himle MB, Woods DW, Piacentini JC, Walkup JT. Brief review of habit reversal training for Tourette syndrome. J Child Neurol. 2006; 21:719–725.

34. Piacentini J, Woods DW, Scahill L, Wilhelm S, Peterson AL, Chang S, et al. Behavior therapy for children with Tourette disorder: a randomized controlled trial. JAMA. 2010; 303:1929–1937.

35. Verdellen CW, Keijsers GP, Cath DC, Hoogduin CA. Exposure with response prevention versus habit reversal in Tourettes's syndrome: a controlled study. Behav Res Ther. 2004; 42:501–511.

36. Gilbert DL, Batterson JR, Sethuraman G, Sallee FR. Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trial. J Am Acad Child Adolesc Psychiatry. 2004; 43:206–214.

37. Yoo HK, Joung YS, Lee JS, Song DH, Lee YS, Kim JW, et al. A multicenter, randomized, double-blind, placebo-controlled study of aripiprazole in children and adolescents with Tourette's disorder. J Clin Psychiatry. 2013; 74:e772–e780.

38. Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric V, Bracken MB, Leckman JF. A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry. 2006; 11:622–632.

39. Tourette's Syndrome Study Group. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. 2002; 58:527–536.

40. Leckman JF, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, et al. Course of tic severity in Tourette syndrome: the first two decades. Pediatrics. 1998; 102:14–19.

41. Plessen KJ. Tic disorders and Tourette's syndrome. Eur Child Adolesc Psychiatry. 2013; 22:Suppl 1. S55–S60.

42. Vaivre-Douret L. Developmental coordination disorders: state of art. Neurophysiol Clin. 2014; 44:13–23.

43. Hadders-Algra M. The neuronal group selection theory: promising principles for understanding and treating developmental motor disorders. Dev Med Child Neurol. 2000; 42:707–715.

44. Edwards J, Berube M, Erlandson K, Haug S, Johnstone H, Meagher M, et al. Developmental coordination disorder in school-aged children born very preterm and/or at very low birth weight: a systematic review. J Dev Behav Pediatr. 2011; 32:678–687.

45. Faebo Larsen R, Hvas Mortensen L, Martinussen T, Nybo Andersen AM. Determinants of developmental coordination disorder in 7-year-old children: a study of children in the Danish National Birth Cohort. Dev Med Child Neurol. 2013; 55:1016–1022.

46. Zwicker JG, Yoon SW, Mackay M, Petrie-Thomas J, Rogers M, Synnes AR. Perinatal and neonatal predictors of developmental coordination disorder in very low birthweight children. Arch Dis Child. 2013; 98:118–122.

47. Gomez A, Sirigu A. Developmental coordination disorder: core sensori-motor deficits, neurobiology and etiology. Neuropsychologia. 2015; 79:272–282.

48. Flapper BC, Schoemaker MM. Developmental coordination disorder in children with specific language impairment: co-morbidity and impact on quality of life. Res Dev Disabil. 2013; 34:756–763.

49. Hill EL. A dyspraxic deficit in specific language impairment and developmental coordination disorder? Evidence from hand and arm movements. Dev Med Child Neurol. 1998; 40:388–395.

50. Kaplan B, Crawford S, Cantell M, Kooistra L, Dewey D. Comorbidity, co-occurrence, continuum: What's in a name? Child Care Health Dev. 2006; 32:723–731.

51. Creavin AL, Lingam R, Northstone K, Williams C. Ophthalmic abnormalities in children with developmental coordination disorder. Dev Med Child Neurol. 2014; 56:164–170.

52. Smits-Engelsman BC, Blank R, van der Kaay AC, Mosterd-van der Meijs R, Vlugt-van den Brand E, Polatajko HJ, et al. Efficacy of interventions to improve motor performance in children with developmental coordination disorder: a combined systematic review and meta-analysis. Dev Med Child Neurol. 2013; 55:229–237.

53. Niemeijer AS, Smits-Engelsman BC, Schoemaker MM. Neuromotor task training for children with developmental coordination disorder: a controlled trial. Dev Med Child Neurol. 2007; 49:406–411.

54. Schoemaker MM, Niemeijer AS, Reynders K, Smits-Engelsman BC. Effectiveness of neuromotor task training for children with developmental coordination disorder: a pilot study. Neural Plast. 2003; 10:155–163.

55. Tsai CL. The effectiveness of exercise intervention on inhibitory control in children with developmental coordination disorder: using a visuospatial attention paradigm as a model. Res Dev Disabil. 2009; 30:1268–1280.

56. Losse A, Henderson SE, Elliman D, Hall D, Knight E, Jongmans M. Clumsiness in children—do they grow out of it? A 10-year follow-up study. Dev Med Child Neurol. 1991; 33:55–68.

57. Rasmussen P, Gillberg C. Natural outcome of ADHD with developmental coordination disorder at age 22 years: a controlled, longitudinal, community-based study. J Am Acad Child Adolesc Psychiatry. 2000; 39:1424–1431.

58. Evans DW, Leckman JF, Carter A, Reznick JS, Henshaw D, King RA, et al. Ritual, habit, and perfectionism: the prevalence and development of compulsive-like behavior in normal young children. Child Dev. 1997; 68:58–68.

59. Baumeister AA, Todd ME, Sevin JA. Efficacy and specificity of pharmacological therapies for behavioral disorders in persons with mental retardation. Clin Neuropharmacol. 1993; 16:271–294.

60. Tröster H, Brambring M, Beelmann A. Prevalence and situational causes of stereotyped behaviors in blind infants and preschoolers. J Abnorm Child Psychol. 1991; 19:569–590.

61. Barry S, Baird G, Lascelles K, Bunton P, Hedderly T. Neurodevelopmental movement disorders - an update on childhood motor stereotypies. Dev Med Child Neurol. 2011; 53:979–985.

62. Gilbert D. Treatment of children and adolescents with tics and Tourette syndrome. J Child Neurol. 2006; 21:690–700.

63. Lancioni GE, Singh NN, O'Reilly MF, Sigafoos J. An overview of behavioral strategies for reducing hand-related stereotypies of persons with severe to profound intellectual and multiple disabilities: 1995-2007. Res Dev Disabil. 2009; 30:20–43.

64. Hugo C, Seier J, Mdhluli C, Daniels W, Harvey BH, Du Toit D, et al. Fluoxetine decreases stereotypic behavior in primates. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27:639–643.

65. Rajapakse T, Pringsheim T. Pharmacotherapeutics of Tourette syndrome and stereotypies in autism. Semin Pediatr Neurol. 2010; 17:254–260.

66. Singer HS. Motor stereotypies. Semin Pediatr Neurol. 2009; 16:77–81.