Cancer Res Treat.  2013 Sep;45(3):239-243.

Angiomatoid Fibrous Histiocytoma as a Second Tumor in a Young Adult with Testicular Cancer

• Lee HS
• Kim T
• Kim JS
• Lee HR
• Joo M
• Park JY
• Yi SY

Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor, with a low-grade malignant potential, occurring predominantly in children and young adults. Association between AFH and other malignancies has been rarely reported. A 27-year-old man who presented with a palpable abdominal mass was diagnosed as having testicular cancer with multiple liver and lung metastases. At 16 months after chemotherapy, a follow-up computed tomographic scan revealed a supraclavicular mass measuring 3 cm in size, which was suspected to be a recurrence. The patient underwent surgical excision, and the mass was pathologically diagnosed as a AFH. The patient has had no local recurrence and no distant metastasis for 12 months after resection. To the best of our knowledge, this is the first case report of AFH as a second tumor in a patient with testicular cancer.

Keyword

Histiocytoma; Angiomatoid fibrous histiocytoma; Second primary neoplasms; Testicular neoplasms

MeSH Terms

Adult
Child
Follow-Up Studies
Histiocytoma
Histiocytoma, Benign Fibrous
Humans
Liver
Lung
Neoplasm Metastasis
Neoplasms, Second Primary
Recurrence
Testicular Neoplasms
Young Adult

Figure

• 

  Fig. 1 (A) Enhanced neck computed tomography showed a well-defined enhancing mass with an internal cystic component in the left supraclavicular area (arrow). (B) Positron emission tomography-computed tomography showed no definite fluorodeoxyglucose uptake in the lesion (arrow).

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  Fig. 2 (A) Low magnification microscopic photograph of the tumor demonstrated fibrohistiocytic proliferation with cystic spaces and a pseudocapsule, surrounded by lymphoid tissue (H&E staining, ×10). (B) The tumor cells were spindle or epithelioid in shape, and were arranged in a nodular pattern (H&E staining, ×100). (C) The tumor cells were positive for CD68 (×200). (D) The tumor cells were focally positive for desmin (×200).

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