Ann Coloproctol.  2015 Dec;31(6):235-242. 10.3393/ac.2015.31.6.235.

Influence of Shorter Duration of Prophylactic Antibiotic Use on the Incidence of Surgical Site Infection Following Colorectal Cancer Surgery

• Park YY
• Kim CW
• Park SJ
• Lee KY
• Lee JJ
• Lee HO
• Lee SH

• KMID: 2150964
• DOI: http://doi.org/10.3393/ac.2015.31.6.235

Abstract

PURPOSE
This study aimed to identify the risk factors for surgical site infections (SSIs) in patients undergoing colorectal cancer surgery and to determine whether significantly different SSI rates existed between the short prophylactic antibiotic use group (within 24 hours) and the long prophylactic antibiotic use group (beyond 24 hours).
METHODS
The medical records of 327 patients who underwent colorectal resection due to colorectal cancer from January 2010 to May 2014 at a single center were retrospectively reviewed, and their characteristics as well as the surgical factors known to be risk factors for SSIs, were identified.
RESULTS
Among the 327 patients, 45 patients (13.8%) developed SSIs. The patients were divided into two groups according to the duration of antibiotic use: group S (within 24 hours) and group L (beyond 24 hours). Of the 327 patients, 114 (34.9%) were in group S, and 213 (65.1%) were in group L. Twelve patients (10.5%) in group S developed SSIs while 33 patients (15.5%) in group L developed SSIs (P = 0.242). History of diabetes mellitus and lung disease, long operation time, and perioperative transfusion were independent risk factors for SSIs.
CONCLUSION
This study shows that discontinuation of prophylactic antibiotics within 24 hours after colorectal surgery has no significant influence on the incidence of SSIs. This study also showed that history of diabetes mellitus and lung disease, long operation time, and perioperative transfusion were associated with increased SSI rates.

Keyword

Antibiotic prophylaxis; Surgical wound infection; Colorectal surgery

MeSH Terms

Anti-Bacterial Agents
Antibiotic Prophylaxis
Colorectal Neoplasms*
Colorectal Surgery
Diabetes Mellitus
Humans
Incidence*
Lung Diseases
Medical Records
Retrospective Studies
Risk Factors
Surgical Wound Infection
Anti-Bacterial Agents