Korean J Pediatr.  2004 Jan;47(1):111-114.

A Case of Tyrosinemia Type 1 with Cytomegalovirus Infection

• Cho JH
• Shim KJ
• Kim SK
• Shin SH
• Lee KH
• Yun HS

Abstract

Tyrosinemia type 1 is an autosomal recessive inborn error of tyrosine metabolism that caused a mutation in the gene coding for the enzyme fumarylacetoacetate hydrolase(FAH). As a result, maleylacetoacetate(MAA) and fumarylacetoacetate(FAA) are formed. The accumulated FAA is converted into succinylacetone(SA) and succinylacetoacetate(SAA) which are excreted in urine. The first report with typical clinical and biochemical findings was presented by Sakai in 1957. Clinically, the disorder is characterized by progressive liver damage with liver failure, a high risk of hepatocellular carcinoma and renal tubular dysfunction hypophosphataemic rickets. Some patients have porphyria-like episodes. Liver transplantation has been the ultimate treatment of tyrosinemia. However pharmacological therapy with 2-(2-nitro-4-trifluoromethylbenzoyl) -1,3-cyclohexanedione(NTBC) has offered a new therapeutic option in addition to dietary restriction of tyrosine and phenylalanine. We experienced a case of tyrosinemia type 1 with cytomegalovirus infection in a 4-month-old male who improved by dietary restriction of tyrosine and phenylalanine.

Keyword

Hereditary tyrosinemia type I; Fumarylacetoacetate hydrolase

MeSH Terms

Carcinoma, Hepatocellular
Clinical Coding
Cytomegalovirus Infections*
Cytomegalovirus*
Humans
Infant
Liver
Liver Failure
Liver Transplantation
Male
Metabolism
Phenylalanine
Rickets
Tyrosine
Tyrosinemias*
Phenylalanine
Tyrosine