Nutr Res Pract.  2008 Dec;2(4):218-226. 10.4162/nrp.2008.2.4.218.

Effects of soybean isoflavone extract on the plasma lipid profiles and antioxidant enzyme activity in streptozotocin-induced diabetic rats

• Shim JY
• Kim YJ
• Lee HS

• KMID: 2139195
• DOI: http://doi.org/10.4162/nrp.2008.2.4.218

Abstract

The present study evaluated the effects of various dosages of soybean isoflavone extract on lipid profiles, lipid peroxidation and antioxidant activities in streptozotocin-induced diabetic rats. The one normal control group was fed an AIN-76-based experimental diet and four diabetic groups were fed the same diet, supplemented with four different levels of soybean isoflavone extract for seven weeks. The daily dosages of pure isoflavone for four diabetic groups were set to be 0 mg (diabetic control), 0.5 mg (ISO-I), 3.0 mg (ISO-II) and 30.0 mg (ISO-III) per kilogram of body weight, respectively. The plasma total cholesterol levels and the TBA-reactive substances contents in the liver and kidney were significantly lowered in ISO-II and ISO-III groups compared to those in the diabetic control group. The levels of plasma HDL-cholesterol, plasma vitamin A and hepatic superoxide dismutase were significantly increased in those two groups compared with the diabetic control group. The present study demonstrated the possibility that the diets supplemented with 3.0 mg and 30.0 mg of soybean isoflavone extract may have beneficial effects on the plasma lipids, tissue lipid peroxidation and partly on antioxidant system in diabetic animals and there were no significant differences between the ISO-II and ISO-III groups. The results suggest that the effective daily dosage level of isoflavone for improving lipid metabolism in diabetic rats may be above 3.0 mg per kilogram body weight.

Keyword

Soybean isoflavone extract; diabetic rat; lipid profiles; antioxidant

MeSH Terms

Animals
Body Weight
Cholesterol
Diet
Kidney
Lipid Metabolism
Lipid Peroxidation
Liver
Plasma
Rats
Soybeans
Superoxide Dismutase
Vitamin A
Cholesterol
Superoxide Dismutase
Vitamin A

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