J Korean Soc Magn Reson Med.  2012 Aug;16(2):136-141. 10.13104/jksmrm.2012.16.2.136.

Pharmacological Functional Magnetic Resonance Imaging of Cloropidol on Motor Task

• Chang Y

• KMID: 2099847
• DOI: http://doi.org/10.13104/jksmrm.2012.16.2.136

Abstract

PURPOSE
To investigate the pharmacologic modulation of motor task-dependent physiologic responses by antiplatelet agent, clopidogrel, during hand motor tasks in healthy subjects.
MATERIALS AND METHODS
Ten healthy, right-handed subjects underwent three functional magnetic resonance (fMRI) sessions: one before drug administration, one after high dose drug administration and one after reaching drug steady state. For the motor task fMRI, finger flexion-extension movements were performed. Blood oxygenation level dependent (BOLD) contrast was collected for each subject using a 3.0 T VHi (GE Healthcare, Milwaukee, USA) scanner. T2*-weighted echo planar imaging was used for fMRI acquisition. The fMRI data processing and statistical analyses were carried out using SPM2.
RESULTS
Second-level analysis revealed significant increases in the extent of activation in the contralateral motor cortex including primary motor area (M1) after drug administration. The number of activated voxels in motor cortex was 173 without drug administration and the number increased to 1049 for high dose condition and 673 for steady-state condition respectively. However, there was no significant difference in the magnitude of BOLD signal change in terms of peak T value.
CONCLUSION
The current results suggest that cerebral motor activity can be modulated by clopidogrel in healthy subjects and that fMRI is highly senstive to evidence such changes.

Keyword

Antiplatelet drug; Functional Magnetic resonance imaging (fMRI); Motor function

MeSH Terms

Delivery of Health Care
Echo-Planar Imaging
Fingers
Hand
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Magnetics
Magnets
Motor Activity
Motor Cortex
Oxygen
Ticlopidine
Oxygen
Ticlopidine

Figure

• 

  Fig. 1 Brain activation maps by right motor task before and after Clopidogrel administration. Left side of the figure corresponds to the left hemisphere.

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