Korean J Obstet Gynecol.  2010 Sep;53(9):851-855. 10.5468/kjog.2010.53.9.851.

Lipomatous variant of angiomyofibroblastoma on the vulva: A case report

• Lee SJ
• Chung YJ
• Lee SH
• Choi YJ
• Kim N
• Son HJ
• Yoon JH

• KMID: 2078005
• DOI: http://doi.org/10.5468/kjog.2010.53.9.851

Abstract

Lipomatous variant of angiomyofibroblastoma is a rare tumor of the vulva. Most of cases are usually premenopausal and present with a slowly growing mass without pain. A 46-year-old woman presented with a swelling of the left labium major. The lesion was thought to be a Batholin's gland cyst or a lipoma preoperatively and a local excision was performed. The tumor was well demarcated and rubbery. On microscopic examination, the alternating hypercellular and edematous hypocellular component with abundant vessels was noted. A large amount of adipose tissue was scattered in the lesion. Stromal cells were positive for vimentin, estrogen receptor, and progesterone receptor and negative for desmin antibody immunostaining. The local excision was enough for complete treatment. No recurrence was noted for 7 months after surgery.

Keyword

Vulva; Angiomyofibroblastoma; Lipomatous variant

MeSH Terms

Adipose Tissue
Desmin
Estrogens
Female
Humans
Lipoma
Middle Aged
Receptors, Progesterone
Recurrence
Stromal Cells
Vimentin
Vulva
Desmin
Estrogens
Receptors, Progesterone
Vimentin

Figure

• 

  Figure 1 Gross appearance of the left vulva and image of computer tomography. (A) The mass was soft and movable. (B) The mass with high enhancement on the left vulva did not infiltrate the adjacent tissue.

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  Figure 2 The surgical specimen of the vulva. The size of mass was 4×3×2 cm sized and showed soft, gelatinous feature.

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  Figure 3 Histologic findings of the vulva mass. (A) The lesion of the vulva had irregular mixture of hypercellular and hypocellular area with prominent blood vessels (H&E stain, ×40). (B) Majority of cells had oval or spindle apperance with an eosinophilic cytoplasm. A lot of adipocytes were scattered. Vessels were encircled with round tumor cells and located in a loose edematous matrix (H&E stain, ×200). (C) Small to medium sized vessels and adipocytes were noted (H&E stain, ×400). (D) Tumor cells were plasmacytoid or epithelioid and multinucleated cells were noted (H&E stain, ×400).

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  Figure 4 Immunohistochemistry findings. (A) positive for vimentin, (B) positive for estrogen receptor, (C) positive for progesterone receptor, (D) negative for desmin.

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