The clinical study of 37 pregnancy women with aplastic anemia

Lee, Keun Ho; Lee, Jong Kun; Yoo, Jin Hee; Lee, Jee Hyun; Jo, Hyeong Kwon; Lee, Ji Young; Kim, Seung Jo; Kim, Soo Pyung

Abstract

Objectives
To determine whether the clinical aspect of aplastic anemia is influenced by pregnancy.
METHODS
We reviewed 37 cases of pregnant aplastic anemia patients during Jan. 1989 to Dec. 1998, and examined age, parity, progress of pregnancy, termination methods, obstetrics & neonatal complications, hematologic change, and treatment modality by medical records. RESULTS: According to onset of disease, patients were divided into pre-pregnant diagnosed group(n=12) and during-pregnancy diagnosed group(n=25). Mean age of diagnosis was 29.4yr, 89.2% were nulliparous, and 51.4% were severe aplastic anemic patients. All patients underwent 50 pregnancy. Mean gestational period was 37wks, birth weight was 2569gram, and, except in 7 cases of abortion, 43 cases were delivered transvaginally or transabdominally(51.2% vs. 48.8%). Preeclampsia, eclampsia, preterm labor, restricted growth, and distress were complicated and decreased hemoglobin, hematocrit, reticulocyte, platelet were reversed after termination in pregnancy associated group. Treatment modality during pregnancy included transfusion, steroid, anti-lymphocytic globulin, anti-thymocytic globulin and IVGV, and remission rate was 45.5% in pregnancy associated group.
CONCLUSION
We concluded that pregnancy is associated with aplastic anemia as a high risk factor, and intensive treatment is needed.