Korean J Urol.  1995 Aug;36(8):802-807.

The Immunohistochemical Study of Changes on Neurotransmitters in Ureteropelvic Junction Obstruction

• Chung SK
• Park YK
• Gonzales E

Abstract

Ureteropelvic junction(UPJ) obstruction is the most common form of obstructive uropathy in the neonate. The etiology of UPJ obstruction is uncertain. Most studies on UPJ obstruction have focused on the histopathology in UPJ complex. In this report we compared the immunoreactivity of neuropeptides including vasointestinal polypeptide(VIP), neuropeptide Y(NPY), dopamine-b- hydroxylase(DBH) in the normal UPJ complex to those of specimens excised at pyeloplasty. We found significant differences between two groups. In the obstructed UPJ specimen there was a relative decrease in concentration and random distribution in localization pattern of NPY in submucosa and muscle. By comparing the normal UPJ with UPJ obstruction, we think that above results provide valuable baseline data on the distribution of neuropeptides within nerves supplying the infant and children's UPJ complex and it may be possible to elucidate further those factors which contribute to UPJ obstruction.

Keyword

Ureteropelvic junction obstruction; Neurotransmitters; Immunohistochemistry

MeSH Terms

Humans
Immunohistochemistry
Infant
Infant, Newborn
Neuropeptides
Neurotransmitter Agents*
Neuropeptides
Neurotransmitter Agents