Korean J Hematol.  1997 Nov;32(3):481-486.

A Case of Waldenstrom's Macroglobulinemia with Multiple Punched-out, Osteolytic Lesions

• Kim SY
• Yoo JY
• Kim WI
• Song DS
• Shim SI

Abstract

Waldenstr m's macroglobulinemia (WM) is a chronic lymphoproliferative disorder characterized by the association of serum monoclonal IgM and marrow infiltration by lymphoid population. A 69-year-old man was first seen for evaluation of anemia. He had complained of generalized weakness and exertional dyspnea. On physical examination there was generalized lymphadenopathy, palpable liver and spleen. He did not show signs and symptoms of hyperviscosity. Skull X-ray demonstrated multiple punched-out, osteolytic lesions. The total serum protein concentration was 10.6g/dL, with a fast gamma peak accounting for 48.3% of the total. The peak was identified as an IgM of the kappa chain type by immunoelectrophoresis. Bence-Jones protein (kappa type) was found in the urine. A Sia test gave positive result. The patient's serum contained a pyroglobulin. Serum viscosity was 5.3. The bone marrow aspirate and biopsy showed infiltration by atypical lymphocytes (about 90% of all nucleated cells), plasmacytic lymphocytes, and plasma cells. By flow cytometric analysis, these cells expressed CD19 (54%), CD20 (80.5%), and CD38 (92%), but did not express CD3, CD5, and CD10. Biopsy specimen from cervical lymph node demonstrated proliferation of abnormal lymphoid cells, composed of a similar population of cells seen in the bone marrow. He was treated with cyclophosphamide, vincristine, and prednisolone and now he improves slightly in clinical and laboratory aspects.

Keyword

Waldenstr m's Macroglobulinemia; Osteolytic lesion; IgM; Kappa chain

MeSH Terms

Aged
Anemia
Biopsy
Bone Marrow
Cyclophosphamide
Dyspnea
Humans
Immunoelectrophoresis
Immunoglobulin M
Liver
Lymph Nodes
Lymphatic Diseases
Lymphocytes
Lymphoproliferative Disorders
Physical Examination
Plasma Cells
Prednisolone
Skull
Spleen
Vincristine
Viscosity
Waldenstrom Macroglobulinemia*
Cyclophosphamide
Immunoglobulin M
Prednisolone
Vincristine