Korean J Anat.  2002 Apr;35(2):173-177.

Immunocytochemical Localization of GABA Transporter-3 in the Guinea Pig Retina

Affiliations
  • 1Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Socho-Ku, Seoul, Korea. mhchun@catholic.ac.kr

Abstract

The cellular localization of the GABA transporter-3 (GAT-3) was examined in the guinea pig retina by immunocytochemistry, using antisera against GAT-3. GAT-3 immunoreactivity was localized to cell bodies in the inner nuclear layer, and labeled processes were densely distributed in the inner plexiform layer (IPL) close to the ganglion cell layer. All GAT-3 labeled cells exhibited GAD65 immunoreactivity. In addition, 67% of GAT-3 labeled amacrine cells showed carbohydrate epitope CD15 immunoreactivity. These results indicate that GAT-3 is involved in modulating the rod pathway in the IPL of the guinea pig retina via presumptive A17 amacrine cells.

Keyword

GABA transporter-3; GAD-65; CD15; Amacrine cells; Immunocytochemistry; Retina; Guinea pig

MeSH Terms

Amacrine Cells
Animals
gamma-Aminobutyric Acid*
Ganglion Cysts
Guinea Pigs*
Guinea*
Immune Sera
Immunohistochemistry
Retina*
Immune Sera
gamma-Aminobutyric Acid
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