Korean Diabetes J.  2010 Aug;34(4):222-228. 10.4093/kdj.2010.34.4.222.

Clinical Characteristics of Type 2 Diabetes Patients according to Family History of Diabetes

• Jeong SU
• Kang DG
• Lee DH
• Lee KW
• Lim DM
• Kim BJ
• Park KY
• Chin HJ
• Koh G

• KMID: 2029875
• DOI: http://doi.org/10.4093/kdj.2010.34.4.222

Abstract

BACKGROUND
Type 2 diabetes mellitus (T2DM) has a strong genetic component, and its prevalence is notably increased in the family members of T2DM patients. However, there are few studies about the family history of T2DM. We carried out this study to assess the influences of family history on clinical characteristics in T2DM patients.
METHODS
This is a cross-sectional study involving 651 T2DM patients. Patient history and physical examination were performed and fasting blood was taken. If any first degree relative was diabetic, a family history of diabetes was considered to exist.
RESULTS
Among the total 621 patients, 38.4% had a family history of diabetes. Patients with a family history had a younger age, higher weight, younger age at diagnosis and higher triglyceride level than did those without a family history. Dyslipidemia medication and metabolic syndrome were more prevalent in familial diabetes. Sex, blood pressure, previous treatment for diabetes, HbA1C, C-peptide, total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were not different between familial and non-familial diabetes. Upon multiple linear regression analysis, the family history of diabetes remained significantly associated with serum triglyceride level.
CONCLUSION
In T2DM patients with a family history of diabetes, the disease tended to develop earlier. Metabolic syndrome and cardiovascular risk factors are more prevalent in familial T2DM than they were in non-familial T2DM. These results support the necessity of earlier screening for diabetes in family members of T2DM patients and more active prevention against cardiovascular disease in T2DM patients with a family history.

Keyword

Diabetes mellitus, type 2; Family history; Metabolic syndrome; Triglyceride

MeSH Terms

Blood Pressure
C-Peptide
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Dyslipidemias
Fasting
Humans
Linear Models
Lipoproteins
Mass Screening
Physical Examination
Prevalence
Risk Factors
C-Peptide
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Lipoproteins

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