J Korean Pediatr Soc.
1997 Mar;40(3):403-407.
Three Cases of Cardiac Arrythmias Associated with Intravenous Methylprednisolone Pulse Therapy
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- Methylprednisolone (MP) is administered by means of intravenous pulse therapy especially in the patients with focal segmental glomerulosclerosis (FSGS). There have been reports of its complications in a few increasing frequency. We experienced three cases of cardiac complications during intravenous pulse therapy. There were one case of 2 A-V block (Mobitz type I) and two cases of bradycardia and hypotension. In the former, 2 A-V block in the first case deveoloped 45 hours after MP infusion and subsided subsequently but reappeared at his EKG checked after 4 months. All of these complications resolved spontaneously. We should be awared of the fact that arrythmia resulting from MP infusion can be fetal. Therefore when IMPT are attempted, we should keep in mind of emergency life-saving preparations at bedside.
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