J Korean Diabetes Assoc.  2007 Mar;31(2):97-104. 10.4093/jkda.2007.31.2.97.

The Roles of Carbon Monoxide in Islets

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Yeungnam University, Korea.

Abstract

No abstract available.


MeSH Terms

Carbon Monoxide*
Carbon*
Carbon
Carbon Monoxide

Figure

  • Fig. 1 Schematic of the heme oxygenase reaction.

  • Fig. 2 The interactions of NO and CO on activating guanylate cyclase pathway.

  • Fig. 3 Summary of the mechanism of CO's protection.

  • Fig. 4 A, Quantitative analysis of HO-1 protein & mRNA expression in freshly isolated murine islets cultured in the presence of FePP; B, FePP-induced HO-1 upregulation results in partial protection from cytokine and Fas-mediated apoptosis induction in βTC3 cells40).

  • Fig. 5 Time course of return to normoglycemia in mice that received a syngeneic marginal mass islet graft. A, time curve to normoglycemia of recipient mice that received FePP-treated islets (● vs control ○). MT to normoglycemia was 36 ± 28.9 days (P = ns); B, Time to normoglycemia of mice that received untreated islets and were treated in vivo with CoPP (□). MT was 33 ± 0.4 days (P = ns); C, Time to normoglycemia in mice that received FePP-treated islets and were treated in vivo with CoPP (■). MT was 18 ± 28.3 days (P = 0.006)40).

  • Fig. 6 Exposure of murine islet to CO improves islet survival/function after transplantation. *P = 0.001 vs. control46).


Reference

1. Von Burg R. Carbon monoxide. J Appl Toxicol. 1999. 19:379–386.
2. Sjostrand T. The formation of carbon monoxide by the decomposition of haemoglobin in vivo. Acta Physiol Scand. 1952. 26:338–344.
3. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA. 1968. 61:748–755.
4. Furchgott RF, Jothianandan D. Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels. 1991. 28:52–61.
5. Frankel D, Mehindate K, Schipper HM. Role of heme oxygenase-1 in the regulation of manganese su perox id e dismutase gene expression in oxidatively-challenged astroglia. J Cell Physiol. 2000. 185:80–86.
6. Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AM. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med. 2000. 6:422–428.
7. Brouard S, Otterbein LE, Anrather J, Tobiasch E, Bach FH, Choi AM, Soares MP. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med. 2000. 192:1015–1026.
8. Tobiasch E, Gunther L, Bach FH. Heme oxygenase-1 protects pancreatic beta cells from apoptosis caused by various stimuli. J Investig Med. 2001. 49:566–571.
9. Ryter SW, Otterbein LE. Carbon monoxide in biology and medicine. Bioassays. 2004. 26:270–280.
10. Morita T. Heme oxygenase and atherosclerosis. Arterioscler Thromb Vasc Biol. 2005. 25:1786–1795.
11. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997. 37:517–554.
12. Applegate LA, Luscher P, Tyrrell RM. Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res. 1991. 51:974–978.
13. Immenschuh S, Ramadori G. Gene regulation of heme oxygenase-1 as a therapeutic target. Biochem Pharmacol. 2000. 60:1121–1128.
14. Weber CM, Eke BC, Maines MD. Corticosterone regulates heme oxygenase-2 and NO synthase transcription and protein expression in rat brain. J Neurochem. 1994. 63:953–962.
15. Dore S, Takahashi M, Ferris CD, Zakhary R, Hester LD, Guastella D, Snyder SH. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci USA. 1999. 96:2445–2450.
16. McDoubrey WK Jr, Hunag TJ, Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem. 1997. 247:725–732.
17. Alam J, Den Z. Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene. J Biol Chem. 1992. 267:21894–21900.
18. Lavrovsky Y, Schwartzman ML, Levere RD, Kappas A, Abraham NG. Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci U S A. 1994. 91:5987–5991.
19. Dalton T, Palmiter RD, Andrews GK. Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res. 1994. 22:5016–5023.
20. Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999. 13:76–86.
21. Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, Cook JL. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem. 1999. 274:26071–26078.
22. Poss KD, Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci U S A. 1997. 94:10925–10930.
23. Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997. 94:10919–10924.
24. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999. 103:129–135.
25. Hentze MW, Kuhn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A. 1996. 93:8175–8182.
26. Choi BM, Pae HO, Jeong YR, Oh GS, Jun CD, Kim BR, Kim YM, Chung HT. Overexpression of heme oxygenase (HO)-1 renders Jurkat T cells resistant to fas-mediated apoptosis: involvement of iron released by HO-1. Free Radical Biology and Medicine. 2004. 36:858–871.
27. Motterlini R, Foresti R, Intaglietta M, Winslow RA. NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium. Am J Physiol. 1996. 270:H107–H114.
28. Choi BM, Pae HO, Kim YM, Chung HT. Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1. Hepatology. 2003. 37:810–823.
29. Zuckerbraun BS, Billiar TR, Otterbein SL, Kim PK, Liu F, Choi AM, Bach FH, Otterbein LE. Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med. 2003. 198:1707–1716.
30. Kozma F, Johnson RA, Zhang F, Yu C, Tong X, Nasjletti A. Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels. Am J Physiol. 1999. 276(4 Pt 2):R1087–R1094.
31. Kajimura M, Shimoyama M, Tsuyama S, Suzuki T, Kozaki S, Takenaka S, Tsubota K, Oguchi Y, Suematsu M. Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina. FASEB J. 2003. 17:506–508.
32. Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S. Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice. Circ Res. 2001. 89:55–62.
33. Petrache I, Otterbein LE, Alam J, Wiegand GW, Choi AM. Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2000. 278:L312–L319.
34. Zhang X, Shan P, Alam J, Davis RJ, Flavell RA, Lee PJ. Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem. 2003. 278:22061–22070.
35. Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis PJ, Choi AM, Lee PJ. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2003. 278:1248–1258.
36. Liu XM, Chapman GB, Peyton KJ, Schafer AI, Durante W. Antiapoptotic action of carbon monoxide on cultured vascular smooth muscle cells. Exp Biol Med. 2003. 228:572–575.
37. Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song R, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FH, Choi AM, Soares MP. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med. 2003. 9:183–190.
38. Pae HO, Oh GS, Choi BM, Chae SC, Kim YM, Chung KR, Chung HT. Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production. J Immunol. 2004. 172:4744–4751.
39. Pae HO, Choi BM, Oh GS, Lee MS, Ryu DG, Rhew HY, Kim YM, Chung HT. Roles of heme oxygenase-1 in the antiproliferative and antiapoptotic effects of nitric oxide on Jurkat T cells. Mol Pharmacol. 2004. 66:122–128.
40. Pileggi A, Molano RD, Berney T, Cattan P, Vizzardelli C, Oliver R, Fraker C, Ricordi C, Pastori RL, Bach FH, Inverardi L. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes. 2001. 50:1983–1991.
41. Brouard S, Berberat PO, Tobiasch E, Seldon MP, Bach FH, Soares MP. Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis. J Biol Chem. 2002. 277:17950–17961.
42. Kurata S, Matsumoto M, Yamashita U. Concomitant transcriptional activation of nitric oxide synthase and heme oxygenase genes during nitric oxide-mediated macrophage cytostasis. J Biochem (Tokyo). 1996. 120:49–52.
43. Li YX, Li G, Dong WP, Lu DR, Tan J. Protection of human islets from induction of apoptosis and improved islet function with HO-1 gene transduction. Chin Med J (Engl). 2006. 119:1639–1645.
44. Won KC, Moon JS, Eun MJ, Yoon JS, Chun KA, Cho IH, Kim YW, Lee HW. A protective role for heme oxygenase-1 in INS-1 cells and rat islets that are exposed to high glucose conditions. J Korean Med Sci. 2006. 21:418–424.
45. Mosen H, Salehi A, Henningsson R, Lundquist I. Nitric oxide inhibits, and carbon monoxide activates, islet acid alpha-glucoside hydrolase activities in parallel with glucose-stimulated insulin secretion. J Endocrinol. 2006. 190:681–693.
46. Gunther L, Berberat PO, Haga M, Brouard S, Smith RN, Soares MP, Bach FH, Tobiasch E. Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation. Diabetes. 2002. 04. 51(4):994–999.
47. Tu CF, Kuo CH, Juang JH. Effects of heme oxygenase-1 transgenic islets on transplantation. Transplant Proc. 2005. 37:3463–3467.
48. Suttner DM, Dennery PA. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J. 1999. 13:1800–1809.
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