Anesth Pain Med.  2009 Apr;4(2):106-112.

The effect of tranexamic acid used for spine surgery on blood loss and transfused volume

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea. siestalee@gmail.com

Abstract

BACKGROUND: In this randomized controlled study, we evaluate the effect of tranexamic acid on perioperative blood loss and transfused volume in patients undergoing spine surgery.
METHODS
We enrolled and randomly allocated 40 patients scheduled for spine surgery under general anesthesia to either tranexamic group or control group. Tranexamic acid was given to tranexamic group with loading dose 10 mg/kg for 15 minutes followed by continuous infusion at the rate of 1 mg/kg/h. In control group, equivalent volume of normal saline was given with the same manner and rate, until the end of procedure. We examined the total blood loss and transfused volume perioperatively. Also we evaluated hemoglobin, platelet, prothrombin time, partial thromboplastin time and thromboelastography before and after surgery.
RESULTS
The groups did not differ significantly. Intraoperative blood loss was 1,130.0 +/-563.9 (mean +/-SD) ml in control group and 1,061.5 +/-509.7 ml in tranexamic group. Blood loss at postoperative 12 h and 24 h were 392.0 +/-222.0 ml, 466.0 +/-323.2 ml in control group and 158.5 +/-100.6 ml, 470.2 +/-232.7 ml in tranexamic group respectively. Transfused volumes at intraoperative and postoperative period were differing significantly (1,300.0 +/-709.3 ml, 800.0 +/-343.3 ml in control group compared to 1,020.0 +/-476.3 ml, 340.0 +/-325.0 ml in tranexamic group).
CONCLUSIONS
Loading dose of 10 mg/kg tranexamic acid and followed infusion at 1 mg/kg/h reduce perioperative blood transfused volume during spinal surgery.

Keyword

antifibrinolytic agents; spinal fusion; tranexamic acid

MeSH Terms

Anesthesia, General
Antifibrinolytic Agents
Blood Platelets
Hemoglobins
Humans
Partial Thromboplastin Time
Postoperative Period
Prothrombin Time
Spinal Fusion
Spine
Thrombelastography
Tranexamic Acid
Antifibrinolytic Agents
Hemoglobins
Tranexamic Acid
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