Korean J Intern Med.  2007 Sep;22(3):152-156. 10.3904/kjim.2007.22.3.152.

The Association Between Current Helicobacter pylori Infection and Coronary Artery Disease

• Jin SW
• Her SH
• Lee JM
• Yoon HJ
• Moon SJ
• Kim PJ
• Baek SH
• Seung KB
• Kim JH
• Kang SB
• Kim JH
• Kim KY

• KMID: 1785620
• DOI: http://doi.org/10.3904/kjim.2007.22.3.152

Abstract

BACKGROUND: The role of Helicobacter pylori (H. pylori) in the pathogenesis of coronary artery disease (CAD) is still controversial, and the relation between current H. pylori infection and CAD has not been fully examined. This study evaluated the relation between H. pylori infection as confirmed by gastroduodenoscopic biopsy and CAD. METHODS: We determined the presence of H. pylori infections, via gastroduodenoscopy, in 88 patients of the normal coronary angiographic group and also in 175 patients of the CAD group, and the latter patients had more than 50% coronary stenosis angiographically demonstrated. We excluded those patients with a history of previous H. pylori eradication and/or malignancy. A small piece of tissue from the antrum, which was obtained by gastroduodenoscopic biopsy, was stained by Warthin-starry silver stain. We defined a negative staining result that there was no stained tissue in the sample and the stained tissue was also positive for H. pylori infection. RESULTS: There was no significant difference, except for gender, age, smoking and high density lipoprotein cholesterol (HDL-c), of the demographic and laboratory characteristics between the groups. Twenty seven (30.7%) patients of the normal control group and 71 (40.6%) patients of the CAD group were positive of H. pylori infection, yet there was no statistical difference. We angiographically followed up the 80 patients of the CAD group who were treated by percutaneous coronary intervention (PCI) at 6 to 9 months after their primary intervention. Twenty two (37.9%) of the 58 patients of the H. pylori negative group and 10 (45.5%) of the 22 patients of the H. pylori positive group were treated with reintervention, but reintervention was also not significantly different between the group with H. pylori infection and the group without the infection. CONCLUSIONS: These data indicated that H. pylori infection had a modest influence on CAD and progressive atheroma, but the showed a tendency to increase. Further studies are needed to evaluate the relationship between H. pylori infection and CAD.

Keyword

Helicobacter pylori; Coronary artery disease

MeSH Terms

Aged
Angioplasty, Transluminal, Percutaneous Coronary
Biopsy
Case-Control Studies
Coronary Angiography
Coronary Artery Disease/*microbiology/radiography/therapy
Duodenoscopy
Female
Gastroscopy
Helicobacter Infections/complications/*microbiology/pathology
Helicobacter pylori/*isolation & purification
Humans
Male
Middle Aged
Pyloric Antrum/pathology
Time Factors