Korean J Pediatr.  2012 Nov;55(11):414-419. 10.3345/kjp.2012.55.11.414.

Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage

• Choi IR
• Lee JH
• Park MS
• Kim JY
• Park KH
• Kim GH
• Eun SH

• KMID: 1781702
• DOI: http://doi.org/10.3345/kjp.2012.55.11.414

Abstract

PURPOSE
This study aimed to assess early development in very low birth weight (VLBW) infants with mild intraventricular hemorrhage (IVH) or those without IVH and to identify the perinatal morbidities affecting early neurodevelopmental outcome.
METHODS
Bayley Scales of Infant Development-II was used for assessing neurological development in 49 infants with a birth weight <1,500 g and with low grade IVH (< or =grade II) or those without IVH at a corrected age of 12 months.
RESULTS
Among the 49 infants, 19 infants (38.8%) showed normal development and 14 (28.6%) showed abnormal mental and psychomotor development. Infants with abnormal mental development (n=14) were mostly male and had a longer hospitalization, a higher prevalence of patent ductus arteriosus (PDA) and bronchopulmonary dysplasia (BPD), and were under more frequent postnatal systemic steroid treatment compared with infants with normal mental development (n=35, P<0.05). Infants with abnormal psychomotor development (n=29) had a longer hospitalization and more associated PDA compared to infants with normal psychomotor development (n=20, P<0.05). Infants with abnormal mental and psychomotor development were mostly male and had a longer hospitalization and a higher prevalence of PDA and BPD compared to infants with normal mental and psychomotor development (n=19, P<0.05). Using multiple logistic regression analysis, a longer duration of hospitalization and male gender were found to be significant risk factors.
CONCLUSION
Approximately 62% of VLBW infants with low grade IVH or those without IVH had impaired early development.

Keyword

Infant premature; Intracranial hemorrhages; Growth & development

MeSH Terms

Birth Weight
Bronchopulmonary Dysplasia
Ductus Arteriosus, Patent
Hemorrhage
Hospitalization
Humans
Infant
Infant, Newborn
Infant, Very Low Birth Weight
Intracranial Hemorrhages
Logistic Models
Male
Prevalence
Weights and Measures