J Korean Soc Magn Reson Med.  2002 Jun;6(1):55-63.

Prediction of Infarction in Acute Cerebral Ischemic Stroke by Using Perfusion MR Imaging and 99mTc-HMPAO SPECT

• Choe HC
• Lee SJ
• Kim JH

Abstract

PURPOSE: We investigated the predictive values of relative CBV measured with perfusion MR imaging, and relative CBF measured with SPECT for tissue outcome in acute ischemic stroke.
MATERIALS AND METHODS
Thirteen patients, who had acute unilateral middle cerebral artery occlusion, underwent perfusion MR imaging, and 99mTc-HMPAO SPECT within 6 hours after the onset of symptoms. Lesion-to-contralateral ratios of perfusion parameters were measured, and best cut-off values of both parameter ratios with their accuracy to discriminate between regions with and without evolving infarction were calculated.
RESULTS
Mean relative CBV ratios in regions with evolving infarction and without evolving infarction were 0.58+/-0.27 and 0.99+/-0.17 (p < 0.001), and mean relative CBF ratios in those regions were 0.41+/-0.22 and 0.71+/-0.14 (p < 0.001). The best cutoff values to discriminate between regions with and without evolving infarction were estimated to be 0.80 for relative CBV ratio and 0.56 for relative CBF ratio. The sensitivity, specificity and efficiency of each cutoff value were 80.6, 87.5, 82.7% for relative CBV ratio, and 72.2, 75.0, 73.0% for relative CBF ratio (p > 0.05 between two parameters).
CONCLUSION
Measurement of relative CBV and relative CBF may be useful in predicting tissue outcome in acute ischemic stroke.

Keyword

Brain, blood flow; Brain, ischemia; MR, perfusion imaging

MeSH Terms

Humans
Infarction*
Infarction, Middle Cerebral Artery
Magnetic Resonance Imaging*
Perfusion*
Sensitivity and Specificity
Stroke*
Technetium Tc 99m Exametazime*
Tomography, Emission-Computed, Single-Photon*
Technetium Tc 99m Exametazime