Korean J Psychopharmacol.  1999 Oct;10(2):191-195.

A Case of Clozapine-Induced Eosinophilia Combined with Bilateral Pleural Effusion, Ascites, Cholecysctitis, and Hepatitis

• Hong HJ
• Kim CH
• Song DH
• Lee SJ
• Lee HS

Abstract

Several blood dyscrasias associated with clozapine have been well known to clinicians and potentially life threatening agranulocytosis has been widely reported. However, there is little report regarding incidence, progression and associated features of eosinophilia associated with clozapine. In clinical studies, the onset of eosinophilia usually occurs artier 3 to 5 weeks of treatment and rarely were cases fatal with medical complication. We report the first case of severe eosinophilia, bilateral pleural effusion, asicites, hepatitis and cholecystitis associated with clozapine that would be fatal. Eosinophilia occurred after 19 days of treatment with clozapine and all the clinical conditions improved along with interruption of clozapine treatment. It is suggested that eosinophilia may be more severe side effort than has ether been known and close hematologic monitoring should be done during early treatment of clozapine.

Keyword

Clozapine; Eosinophilia

MeSH Terms

Agranulocytosis
Ascites*
Cholecystitis
Clozapine
Eosinophilia*
Ether
Hepatitis*
Incidence
Pleural Effusion*
Clozapine
Ether