Infect Chemother.  2010 Aug;42(4):257-261. 10.3947/ic.2010.42.4.257.

Three Reinfection Cases of the Pandemic Influenza (H1N1 2009)

• Kim TS
• Ho KM
• Yim KR
• Oh WS
• Chon SB
• Ryu SW
• Yie K
• Lee SJ

• KMID: 1457389
• DOI: http://doi.org/10.3947/ic.2010.42.4.257

Abstract

Infection with influenza virus results in acquisition of immunity, preventing reinfection with the homologous virus. Although reinfection following primary infection is rare, its incidence depends on immunity of human body, antigenic diversity of influenza virus, and the presence of outbreak in the community. During the pandemic influenza (H1N1 2009), a child and two women were reinfected by H1N1 influenza virus several weeks after the primary infection, and they were successfully treated again by oseltamivir. This case series will provide additional information on diagnosis, treatment, and prevention of the pandemic influenza (H1N1 2009).

Keyword

Pandemic influenza (H1N1 2009); Reinfection; Immunity

MeSH Terms

Antigenic Variation
Child
Female
Human Body
Humans
Incidence
Influenza, Human
Orthomyxoviridae
Oseltamivir
Pandemics
Viruses
Oseltamivir

Figure

• 

  Figure 1 (A) Electrophoresis of PCR products of cDNA after neuraminidase gene sequencing from the 2009 H1N1 influenza virus RNA. (B) Alignment results of genome segment 6 of the 2009 H1N1 influenza virus. 1, first episode of case 1; 2, second episode of case 1; 3, first episode of case 2; 4, second episode of case 2; 5, first episode of case 3; 6, second episode of case 3; L, 100 bp ladder; N, negative control. Red-lined box indicates H275Y mutation site, which is conserved in all samples of 3 cases.

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