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Possible Roles of UL112-113 Proteins in Human Cytomegalovirus DNA Replication

Kim YE, Ahn JH

DNA replication of human cytomegalovirus (HCMV) is a highly regulated process that requires specific interactions between cis-acting lytic origin of replication (oriLyt) and trans-acting viral proteins. Formation of the replication...
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Herpesvirus-encoded Deubiquitinating Proteases and Their Roles in Regulating Immune Signaling Pathways

Kwon KM, Ahn JH

Viruses interact with the host ubiquitination system in a variety of ways. Viral proteins are often a substrate for ubiquitination, which leads to proteasomal degradation. Viruses also have functions to...
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Human Immunodeficiency Virus Type 1 Tat-Mediated Cellular Response in Myeloid Cells

Kim NY, Kim YW

Human immunodeficiency virus type 1 (HIV-1)-infected cells respond to the infection with different outcomes depending on their cell type. The interplay of cellular and viral proteins is a key player...
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The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract

Nicholls J

  • KMID: 2391836
  • Infect Chemother.
  • 2013 Mar;45(1):11-21.
Influenza is a viral infection of the respiratory tract. Infection is normally confined to the upper respiratory tract but certain viral strains have evolved the ability to infect the lower...
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Expression of the Structural Proteins of Japanese Encephalitis Virus

Kang SY, Yun SI, Lim YH, Lee YM

  • KMID: 2054989
  • J Bacteriol Virol.
  • 2004 Mar;34(1):75-81.
Japanese encephalitis virus (JEV) is one of the most important human pathogens, which causes the permanent neuropsychiatric sequelae and even fatal diseases with high mortality and morbidity, especially among children....
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Hepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise

Walsh R, Locarnini

  • KMID: 2453943
  • Yonsei Med J.
  • 2012 Sep;53(5):875-885.
Hepatitis B virus (HBV), a small and economically packaged double-stranded DNA virus, represents an enormous global health care burden. In spite of an effective vaccine, HBV is endemic in many...
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Mapping of Human Cytomegalovirus IE1 Responsive Elements in the c-jun Promoter

Kim DJ, Kim JH, Choi SB, Han TH, Park CG, Hwang ES, Cha CY

  • KMID: 1551995
  • J Korean Soc Virol.
  • 1998 Sep;28(3):267-274.
Human cytomegalovirus (HCMV) has the ability to activate the espremission of many viral and cellular genes. Among various viral proteins, the immediate early proteins (IE1-72kDa, IE2-86kDa) have been known to...
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Development of Enzyme-Linked Immunosorbent Assays Using 2 Truncated ORF2 Proteins for Detection of IgG Antibodies Against Hepatitis E Virus

Taherkhani R, Makvandi M, Farshadpour F

BACKGROUND: Without appropriate culture systems for hepatitis E virus (HEV), sufficient natural viral proteins are difficult to generate for use in serological tests. Therefore, it is important to produce large...
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Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients

Park KJ, Lee J, Park JH, Joh JW, Kwon CH, Kim JW

BACKGROUND: The incidence and etiology of hepatocellular carcinoma (HCC) vary widely according to race and geographic regions. The insertional mutagenesis of adeno-associated virus 2 (AAV2) has recently been considered a...
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Expression of Open Reading Frame 5 Protein of Porcine Reproductive and Respiratory Syndrome Virus Using Semliki Forest Virus Expression System

Jung HS, Hwang IW, Kim SM, Kim CJ, Shin KS, Kim HS

  • KMID: 1101569
  • J Vet Sci.
  • 2002 Mar;3(1):13-18.
The ORF5 gene encodes a major envelope glycoprotein (GP5), which is one of the three major proteins of porcine reproductive and respiratory syndrome virus (PRRSV). The GP5 protein has been...
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Distribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens in nervous and non-nervous organs of European seabass (Dicentrarchus labrax) during the course of an experimental challenge

Lopez-Jimena B, Garcia-Rosado E, Thompson K, Adams A, Infante C, Borrego JJ, Alonso MD

  • KMID: 2391993
  • J Vet Sci.
  • 2012 Dec;13(4):355-362.
The distribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens was examined by immunohistochemistry in the nervous and non-nervous organs of juvenile European seabass (Dicentrarchus labrax) during the course of...
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Immunogenicity of recombinant Lactobacillus plantarum NC8 expressing goose parvovirus VP2 gene in BALB/c mice

Liu YY, Yang WT, Shi SH, Li YJ, Zhao L, Shi CW, Zhou FY, Jiang YL, Hu JT, Gu W, Yang GL, Wang CF

Goose parvovirus (GPV) continues to be a threat to goose farms and has significant economic effects on the production of geese. Current commercially available vaccines only rarely prevent GPV infection....
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Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity

Lee MJ, Jin YH, Kim K, Choi Y, Kim HC, Park S

BACKGROUND: CD8+ T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8+ T cell response may be one of the major factors leading to...
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Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus

Lv L, Li X, Liu G, Li R, Liu Q, Shen H, Wang W, Xue C, Cao Y

Infectious bronchitis virus (IBV) poses a severe threat to the poultry industry and causes heavy economic losses worldwide. Vaccination is the most effective method of preventing infection and controlling the...
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Possible Transfusion-Related Acute Lung Injury Following Convalescent Plasma Transfusion in a Patient With Middle East Respiratory Syndrome

Chun S, Chung CR, Ha YE, Han TH, Ki CS, Kang ES, Park JK, Peck KR, Cho D

No abstract available.
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T Cell Epitope Analysis of Structural Protein of Adenovirus

Hwang JW, Kim MH, Kim KH

  • KMID: 1557251
  • Korean J Immunol.
  • 1998 Dec;20(4):435-442.
Thelper (Th) cells play a pivotal role in the regulation of immune responses. Since Th epitopes in adenovirus have not yet been defined, in this study, it was attempted to...
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New vaccines against influenza virus

Lee YT, Kim KH, Ko EJ, Lee YN, Kim MC, Kwon YM, Tang Y, Cho MK, Lee YJ, Kang SM

Vaccination is one of the most effective and cost-benefit interventions that prevent the mortality and reduce morbidity from infectious pathogens. However, the licensed influenza vaccine induces strain-specific immunity and must...
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Molecular characterization and phylogenetic analysis of pseudorabies virus variants isolated from Guangdong province of southern China during 2013–2014

Fan J, Zeng X, Zhang G, Wu Q, Niu J, Sun B, Xie Q, Ma J

Outbreaks of pseudorabies (PR) have occurred in southern China since late 2011, resulting in significant economic impacts on the swine industry. To identify the cause of PR outbreaks, especially among...
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Genotyping Influenza Virus by Next-Generation Deep Sequencing in Clinical Specimens

Seong MW, Cho SI, Park H, Seo SH, Lee SJ, Kim EC, Park SS

Rapid and accurate identification of an influenza outbreak is essential for patient care and treatment. We describe a next-generation sequencing (NGS)-based, unbiased deep sequencing method in clinical specimens to investigate...
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Deletion within LMP-1 Oncogene in Hodgkin's Disease in Korea

Kwon GY, Ahn WS, Lee BY, Lee SS, Huh J, Kim CW

  • KMID: 1725430
  • Korean J Pathol.
  • 1998 Sep;32(9):638-646.
LMP (latent membrane protein)-1 protein is one of the Epstein-Barr viral proteins and it is the most crucial one for the transforming activity. It is known to show considerable variation...
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