- DNA Vaccines
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Sung SY
- KMID: 2349108
- J Korean Med Assoc.
- 1997 Jan;40(1):132-141.
No abstract available. -
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- DNA vaccines targeting human papillomavirus-associated diseases: progresses in animal and clinical studies
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Han KT, Sin JI
- KMID: 2167720
- Clin Exp Vaccine Res.
- 2013 Jul;2(2):106-114.
- doi: 10.7774/cevr.2013.2.2.106
Human papillomavirus (HPV) infection is a major cause of cervical cancer and its precancerous diseases. Cervical cancer is the second deadliest cancer killer among women worldwide. Moreover, HPV is also... -
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- Microneedle patches for vaccine delivery
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Suh H, Shin J, Kim YC
- KMID: 2049095
- Clin Exp Vaccine Res.
- 2014 Jan;3(1):42-49.
- doi: 10.7774/cevr.2014.3.1.42
In today's medical industry, the range of vaccines that exist for administration in humans represents an eclectic variety of forms and immunologic mechanisms. Namely, these are the live attenuated viruses,... -
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- New Vaccine Technology for Control of Emerging and Reemerging Infectious Diseases
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Kang JH
- KMID: 2303880
- Korean J Epidemiol.
- 2006 Jun;28(1):41-46.
Although the development of vaccines has been one of the most important contributions of immunology to medicine and public health, and despite vaccination having been proven as the most effective... -
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- Recent progress in microneme-based vaccines development against Toxoplasma gondii
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Foroutan M, Zaki L, Ghaffarifar F
- KMID: 2418087
- Clin Exp Vaccine Res.
- 2018 Jul;7(2):93-103.
- doi: 10.7774/cevr.2018.7.2.93
Toxoplasmosis is a cosmopolitan zoonotic disease, which infect several warm-blooded mammals. More than one-third of the human population are seropositive worldwide. Due to the high seroprevalence of Toxoplasma gondii infection... -
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- Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases
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Grunwald T, Ulbert S
- KMID: 2049102
- Clin Exp Vaccine Res.
- 2015 Jan;4(1):1-10.
- doi: 10.7774/cevr.2015.4.1.1
Advantages of DNA vaccination against infectious diseases over more classical immunization methods include the possibilities for rapid manufacture, fast adaptation to newly emerging pathogens and high stability at ambient temperatures.... -
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- Perspectives of AIDS Vaccine Development T Cell-based Vaccine
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Sung YC
- KMID: 1571385
- Immune Netw.
- 2002 Mar;2(1):1-5.
- doi: 10.4110/in.2002.2.1.1
Estimated number of adults and children newly infected with HIV-1 during 2001 alone is 5 million in total. An effective vaccine, in addition to education & public health approaches, has... -
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- Porcine reproductive and respiratory syndrome virus vaccine does not fit in classical vaccinology
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Lyoo YS
- KMID: 1965400
- Clin Exp Vaccine Res.
- 2015 Jul;4(2):159-165.
- doi: 10.7774/cevr.2015.4.2.159
All vaccines are developed to elicit an effective immune response in vaccinated animals such as innate, humoral and cell mediated response to protect animal health. Quality and intensity of the... -
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- Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys
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Park SH, Song MY, Nam HJ, Im SJ, Sung YC
- KMID: 2150675
- Immune Netw.
- 2010 Dec;10(6):198-205.
- doi: 10.4110/in.2010.10.6.198
BACKGROUND: A crucial limitation of DNA vaccines is its weak immunogenicity, especially in terms of eliciting antibody responses in non-human primates or humans; therefore, it is essential to enhance immune... -
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- Construction of Recombinant DNA with F and HN Genes of Newcastle Disease Virus and Its Immunogenicity
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Kim JY, Chu J, Park JH, Seo SH, Park CS, Kim MC, Jun MH
- KMID: 2055016
- J Bacteriol Virol.
- 2006 Jun;36(2):99-107.
- doi: 10.4167/jbv.2006.36.2.99
Recombinant DNA vaccines, based on plasmid vectors expressing an antigen under the control of a strong promotor, have several advantages over traditional vaccines. They have been shown to induce a... -
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- Preferential production of IgM-secreting hybridomas by immunization with DNA vaccines coding for Ebola virus glycoprotein: use of protein boosting for IgG-secreting hybridoma production
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Lee SH, Han BS, Choe J, Sin JI
- KMID: 2391574
- Clin Exp Vaccine Res.
- 2017 Jul;6(2):135-145.
- doi: 10.7774/cevr.2017.6.2.135
PURPOSE: The goal of this study was to investigate the utility of DNA vaccines encoding Ebola virus glycoprotein (GP) as a vaccine type for the production of GP-specific hybridomas and... -
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- Immunogenicity and efficacy of a plasmid DNA rabies vaccine incorporating Myd88 as a genetic adjuvant
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Ullas PT, Desai A, Madhusudana SN
- KMID: 1730625
- Clin Exp Vaccine Res.
- 2014 Jul;3(2):202-211.
- doi: 10.7774/cevr.2014.3.2.202
PURPOSE: Myeloid differentiation factor 88 (Myd88), a ubiquitous Toll-like receptor adaptor molecule, has been reported to play important roles in B cell responses to infections and vaccination. The present study... -
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- Improved immunogenicity of Newcastle disease virus inactivated vaccine following DNA vaccination using Newcastle disease virus hemagglutinin-neuraminidase and fusion protein genes
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Firouzamandi M, Moeini H, Hosseini D, Bejo MH, Omar AR, Mehrbod P, Ideris A
- KMID: 2363331
- J Vet Sci.
- 2016 Mar;17(1):21-26.
- doi: 10.4142/jvs.2016.17.1.21
The present study describes the development of DNA vaccines using the hemagglutinin-neuraminidase (HN) and fusion (F) genes from AF2240 Newcastle disease virus strain, namely pIRES/HN, pIRES/F and pIRES-F/HN. Transient expression... -
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- Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity
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Kim AR, Park J, Kim JH, Kwak JE, Cho Y, Lee H, Jeong M, Park SH, Shin EC
- KMID: 2424204
- Immune Netw.
- 2018 Oct;18(5):e38.
- doi: 10.4110/in.2018.18.e38
Herpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from the sensory ganglia when VZV-specific T-cell immunity is decreased because of aging or immunosuppression.... -
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- Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine
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Yan F, Zhao Y, Hu Y, Qiu J, Lei W, Ji W, Li X, Wu Q, Shi X, Li Z
- KMID: 1482813
- J Vet Sci.
- 2013 Mar;14(1):53-60.
- doi: 10.4142/jvs.2013.14.1.53
The protective efficacy of DNA plasmids encoding avian infectious bronchitis virus (IBV) S1, N, or M protein was investigated in chickens. Chickens were inoculated monovalently (with plasmid pVAX1-16S1, pVAX1-16M, or... -
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- DNA-mediated immunization of mice with plasmid encoding HBs antigen
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Yoon SJ, Park JW, Ahn SY, Choe BK, Suh MH
- KMID: 648079
- J Korean Med Sci.
- 1999 Apr;14(2):187-192.
- doi: 10.3346/jkms.1999.14.2.187
In order to develop an experimental DNA vaccine for the prevention and treatment of hepatitis B virus infection, hepatitis B virus surface antigen (HBsAg) DNA was subcloned into an E.... -
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- DNA vaccines for cervical cancer: from bench to bedside
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Hung CF, Monie A, Alvarez RD, Wu TC
- KMID: 1091062
- Exp Mol Med.
- 2007 Dec;39(6):679-689.
More than 99% of cervical cancers have been associated with human papillomaviruses (HPVs), particularly HPV type 16. The clear association between HPV infection and cervical cancer indicates that HPV serves... -
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- DNA immunization of Mycobacterium tuberculosis resuscitation-promoting factor B elicits polyfunctional CD8+ T cell responses
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Lee J, Kim J, Lee J, Shin SJ, Shin EC
- KMID: 1730629
- Clin Exp Vaccine Res.
- 2014 Jul;3(2):235-243.
- doi: 10.7774/cevr.2014.3.2.235
PURPOSE: T cell-mediated immune responses, and particularly activation of polyfunctional T cells that simultaneously produce multiple cytokines, are necessary for the control of Mycobacterium tuberculosis. In the present study, we... -
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- DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice
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Han Y, Zhou A, Lu G, Zhao G, Sha W, Wang L, Guo J, Zhou J, Zhou H, Cong H, He S
- KMID: 2395754
- Korean J Parasitol.
- 2017 Oct;55(5):505-512.
- doi: 10.3347/kjp.2017.55.5.505
Toxoplasma gondii cathepsin C proteases (TgCPC1, 2, and 3) are important for the growth and survival of T. gondii. In the present study, B-cell and T-cell epitopes of TgCPC1 were... -
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- Rhoptry antigens as Toxoplasma gondii vaccine target
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Foroutan M, Ghaffarifar F, Sharifi Z, Dalimi A, Jorjani O
- KMID: 2438956
- Clin Exp Vaccine Res.
- 2019 Jan;8(1):4-26.
- doi: 10.7774/cevr.2019.8.1.4
Toxoplasmosis is a cosmopolitan zoonotic infection, caused by a unicellular protozoan parasite known as Toxoplasma gondii that belongs to the phylum Apicomplexa. It is estimated that over one-third of the... -
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