- Pharmacokinetics of Uridine Following Ocular, Oral and Intravenous Administration in Rabbits
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Kim E, Kang W
- KMID: 1502520
- Biomol Ther.
- 2013 Mar;21(2):170-172.
The pyrimidine nucleoside uridine has recently been reported to have a protective effect on cultured human corneal epithelial cells, in an animal model of dry eye and in patients. In... -
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- Development of inhibitors of pyrimidine metabolism
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Cha S
- KMID: 1105559
- Yonsei Med J.
- 1989 Dec;30(4):315-326.
- doi: 10.3349/ymj.1989.30.4.315
Benzylacyclouridines were developed as specific and potent competitive inhibitors of uridine phosphorylase with Ki values in the nanomolar range. These compounds have no activity against thymidine phosphorylase, uridine kinase,... -
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- Galactosemia
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Yang SH
- KMID: 2168071
- Hanyang Med Rev.
- 2005 Aug;25(3):37-41.
Galactosemia, a term that denotes the presence of galactose in the blood, is the name of rare inborn error of galactose metabolism due to a deficiency of the enzyme galactokinase... -
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- Effects of Uridine 5'-Triphosphate on the Vascular Tone of Rat Thoracic Aorta
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Park KS, Kong ID, Lee JW
- KMID: 2228958
- Korean Circ J.
- 1995 Feb;25(1):68-77.
- doi: 10.4070/kcj.1995.25.1.68
BACKGROUND: Uracil nucleotides are stored in platelets and all other cells, and are released into the extracellular space upon stimulation. They show various biological responses but their actions and mechanism... -
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- Effects of Homogentisic Acid and Natural Products Derived from Pinellia ternata on Secretion, Production and Gene Expression of MUC5AC Mucin from Cultured Airway Epithelial Cells
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Lee HJ, Lee CJ
- KMID: 2376496
- Nat Prod Sci.
- 2017 Mar;23(1):29-34.
- doi: 10.20307/nps.2017.23.1.29
In this study, we investigated whether adenosine, adenine, uridine and homogentisic acid derived from Pinellia ternata affect the secretion, production and gene expression of MUC5AC mucin from airway epithelial cells.... -
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- Effect of Uridine 5'-Triphosphate on Mucin Secretion in Human Middle Ear Epithelial Cells
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Choi JY, Lim JT, Yoon JH
- KMID: 2275992
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Feb;46(2):100-104.
BACKGROUND AND OBJECTIVES: Extracellular uridine 5'-triphosphate (UTP) regulates a variety of biological functions in the airway epithelium including chloride and fluid transport, mucociliary clearance, and mucin secretion via P2Y purinergic... -
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- Effects of pyrimidine salvage inhibitors on uracil incorporation of Toxoplasma gondii
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Youn JH, Nam HW, Kim DJ, Choi WY
- KMID: 1043393
- Korean J Parasitol.
- 1990 Jun;28(2):79-84.
- doi: 10.3347/kjp.1990.28.2.79
Metabolic inhibitors which act in the process of pyrimidine salvage influenced on the uracil incorporation into nucleic acids of Toxoplasma. Inhibitors of dihydrofolate reductase, pyrimethamine and methotrexate, and inhibitors of... -
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- Hope for Cirrhosis Patients with Genotype 1 Hepatitis C Virus Who Failed the Previous Treatment
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Kwon JH
- KMID: 2373327
- Korean J Gastroenterol.
- 2015 Aug;66(2):131-133.
- doi: 10.4166/kjg.2015.66.2.131
No abstract available. -
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- Preliminary Effects of Oral Uridine on the Ocular Surface in Dry Eye Patients
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Chang KC, Oh JY, In YS, Kim MK, Shin KC, Wee WR, Lee JH, Park MG
- KMID: 1779207
- J Korean Med Sci.
- 2009 Aug;24(4):701-707.
- doi: 10.3346/jkms.2009.24.4.701
We designed a randomized, double blinded, 3-months controlled prospective clinical study to investigate effects of oral uridine on the ocular surface in dry eye patients. Twenty-seven patients who diagnosed as... -
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- Isolation and Structure Determination of an Imidazo-pyrimidine, 5-Chlorocavernicolin, Maleimide oximes and Nucleosides from a Marine Sponge Extract
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Kulkarni R, Kim JH, Kim YH, Oh S, Na M
- KMID: 2409595
- Nat Prod Sci.
- 2015 Mar;21(1):25-29.
- doi: 10.0000/nps.2015.21.1.25
In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation... -
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- Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp.
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Jia YL, Guan FF, Ma J, Wang CY, Shao CL
- KMID: 2312900
- Nat Prod Sci.
- 2015 Dec;21(4):227-230.
- doi: 10.20307/nps.2015.21.4.227
Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3... -
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- A Case of Gilbert's Syndrome with Severe Neonatal Hyperbilirubinemia
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Hong YS, Jin JY, Lee WR
- KMID: 2321501
- J Korean Soc Neonatol.
- 2010 Nov;17(2):266-269.
Gilbert's syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population... -
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- The Protective Effect of Mannitol and Methylprednisolone in the Acute Focal Cerebral Ischemia in Cats
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Shin KM
- KMID: 2170822
- Ewha Med J.
- 1988 Dec;11(4):283-297.
- doi: 10.12771/emj.1988.11.4.283
It is the purpose of the this experimental study to investigate the protective effect of pretreatment of mannitol and methylprednisolone(MP) on the changes of the high-energy metabolites(nucleotides ; derivatives of... -
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- Molecular Analysis of the UGT1A1 Gene in Korean Patients with Crigler-Najjar Syndrome Type II
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Ko JS, Chang JY, Moon JS, Yang HR, Seo JK
- KMID: 2315463
- Pediatr Gastroenterol Hepatol Nutr.
- 2014 Mar;17(1):37-40.
PURPOSE: Crigler-Najjar syndrome type II (CN-2) is characterized by moderate non-hemolytic unconjugated hyperbilirubinemia as a result of severe deficiency of bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1). The study investigated the mutation spectrum... -
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- Asymmetrical distribution of P2Y nucleotide receptors in rabbit inner medullary collecting duct cells
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Woo JS, Jung JS, Kim YK
- KMID: 1917024
- Korean J Physiol Pharmacol.
- 2000 Aug;4(4):311-318.
We cultured the rabbit inner medullary collecting duct (IMCD) cells as monolayers on collagen-coated membrane filters, and investigated distribution of the P2Y receptors by analyzing nucleotide-induced short circuit current (Isc) responses. Exposure to... -
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- Chemical Constituents of the Fruiting Bodies of Clitocybe nebularis and Their Antifungal Activity
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Kim YS, Lee IK, Seok SJ, Yun BS
- KMID: 2411406
- Mycobiology.
- 2008 Jun;36(2):110-113.
During a continuing search for antimicrobial substances from Korean native wild mushroom extracts, we found that the methanolic extract of the fruiting body of Clitocybe nebularis exhibited mild antifungal activity... -
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- Curcumin modulates the apolipoprotein B mRNA editing by coordinating the expression of cytidine deamination to uridine editosome components in primary mouse hepatocytes
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He P, Tian N
- KMID: 2443606
- Korean J Physiol Pharmacol.
- 2019 May;23(3):181-189.
- doi: 10.4196/kjpp.2019.23.3.181
Curcumin, an active ingredient of Curcuma longa L., can reduce the concentration of low-density lipoproteins in plasma, in different ways. We had first reported that curcumin exhibits hypocholesterolemic properties by... -
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- Correlation between laxative effects of uridine and suppression of ER stress in loperamide induced constipated SD rats
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Kim JE, Song BR, Yun WB, Choi JY, Park JJ, Lee MR, Hwang DY
- KMID: 2402266
- Lab Anim Res.
- 2017 Dec;33(4):298-307.
- doi: 10.5625/lar.2017.33.4.298
A correlation between endoplasmic reticulum (ER) stress and laxative effects was first reported in a constipation model treated with an aqueous extract of Liriope platyphylla (AEtLP) roots. To investigate the... -
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- Modulators of Ion Transport in Nasal Polyps: An in situ Measurement of Short-Circuit Current
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Lee JH, Rhee CS, Kim DW, Lee CH
- KMID: 1486057
- Clin Exp Otorhinolaryngol.
- 2008 Jun;1(2):75-79.
- doi: 10.3342/ceo.2008.1.2.75
OBJECTIVES: To examine possible modulators of the ion transport through the apical membrane of the nasal polyps. METHODS: The study was conducted using the freshly-excised nasal polyps from the patients... -
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- Intrahepatic Arterio-Venous Shunts in a Patient with Hypergalactosemia Detected by Neonatal Screening
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Hong JH, Um JP, Cha BH, Lim BK, Kim JS
- KMID: 2188642
- J Korean Soc Neonatol.
- 2004 May;11(1):87-92.
We report a case of 15 days old newborn presenting with hypergalactosemia detected by newborn screening who had intrahepatic arterio-venous shunts with multiple pin-head sized cutaneous hemangiomas. Plasma level of... -
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