- The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi
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Liu TB, Xue C
- KMID: 2312649
- Mycobiology.
- 2011 Dec;39(4):243-248.
The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating... -
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- Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
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Song Y, Lee S, Kim JR, Jho EH
- KMID: 2429557
- Int J Stem Cells.
- 2018 Nov;11(2):242-247.
- doi: 10.15283/ijsc18032
Ubiquitination of proteins plays an essential role in various cellular processes, including protein degradation, DNA repair, and cell signaling pathways. Previous studies have shown that protein ubiquitination is implicated in... -
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- The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
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Lee HJ
- KMID: 2447447
- J Cancer Prev.
- 2018 Dec;23(4):162-169.
- doi: 10.15430/JCP.2018.23.4.162
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated... -
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- F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
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Lee KW, Kwak SH, Koo YD, Cho YK, Lee HM, Jung HS, Cho YM, Park YJ, Chung SS, Park KS
- KMID: 2361521
- Exp Mol Med.
- 2016 May;48(5):e234.
- doi: 10.1038/emm.2016.31
Peroxisome proliferator-activated receptor gamma (PPARγ) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Post-translational modification of PPARγ and its degradation involve several pathways, including... -
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- Selective expression of death receptor 4 and induction of apoptosis by HPV E6
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Choi E, Koh H, Shin S, Kim K
- KMID: 2244946
- Korean J Gynecol Oncol Colposc.
- 2002 Jun;13(2):139-145.
Human papillomaviruses, especially type 16 and 18, have been known to be closely associated with human cervix cancer. The E6 and E7 proteins encoded by these viruses disrupt normal cell... -
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- Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control
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Jung Y, Kim HD, Yang HW, Kim HJ, Jang CY, Kim J
- KMID: 2396795
- Exp Mol Med.
- 2017 Nov;49(11):e390.
- doi: 10.1038/emm.2017.128
When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have... -
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- Identification and Molecular Characterization of Parkin in Clonorchis sinensis
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Bai X, Kim TI, Lee JY, Dai F, Hong SJ
- KMID: 2381798
- Korean J Parasitol.
- 2015 Feb;53(1):65-75.
- doi: 10.3347/kjp.2015.53.1.65
Clonorchis sinensis habitating in the bile duct of mammals causes clonorchiasis endemic in East Asian countries. Parkin is a RING-between-RING protein and has E3-ubiquitin ligase activity catalyzing ubiquitination and degradation... -
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- Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth
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Kim D, Koh J, Ko JS, Kim HY, Lee H, Chung DH
- KMID: 2461196
- Immune Netw.
- 2019 Oct;19(5):e32.
- doi: 10.4110/in.2019.19.e32
Pellino-1 is a ubiquitin (Ub) E3 ligase that plays a role in M1, but not M2a polarization of macrophages. However, it is unknown whether Pellino-1 regulates IL-10-mediated M2c polarization of... -
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- Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65
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Lee EJ, Hyun S, Chun J, Shin SH, Kang SS
- KMID: 1119321
- Exp Mol Med.
- 2009 Aug;41(8):555-568.
- doi: 10.3858/emm.2009.41.8.061
Fe65 has been characterized as an adaptor protein, originally identified as an expressed sequence tag (EST) corresponding to an mRNA expressed at high levels in the rat brain. It contains... -
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- Phospholipase D2 promotes degradation of hypoxia-inducible factor-1alpha independent of lipase activity
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Park MH, Bae SS, Choi KY, Min DS
- KMID: 2359883
- Exp Mol Med.
- 2015 Nov;47(11):e196.
- doi: 10.1038/emm.2015.87
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1alpha protein... -
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- Anaphase-Promoting Complex 7 is a Prognostic Factor in Human Colorectal Cancer
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Kim IY, Kwon HY, Park KH, Kim DS
- KMID: 2391456
- Ann Coloproctol.
- 2017 Aug;33(4):139-145.
- doi: 10.3393/ac.2017.33.4.139
PURPOSE: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity and is required for ubiquitination of securin and cyclin-B. Several APC-targeting molecules are reported to be... -
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- SUMO Proteins are not Involved in TGF-beta1-induced, Smad3/4-mediated Germline alpha Transcription, but PIASy Suppresses it in CH12F3-2A B Cells
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Lee SH, Kim PH, Oh SM, Park JH, Yoo YC, Lee J, Park SR
- KMID: 2150822
- Immune Netw.
- 2014 Dec;14(6):321-327.
- doi: 10.4110/in.2014.14.6.321
TGF-beta induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-beta signal-transducing transcription factors, mediate germline (GL) alpha transcription induced by TGF-beta1, resulting in... -
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- B-cell Acute Lymphoblastic Leukemia With t(9;22)(q34;q11) Translocation and Clonal Divergence Through ider(22) Chromosome and t(13;17)(q14;q25) Translocation
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Meza-Espinoza JP, Romo Martinez EJ, Aguilar Lopez L, Picos Cardenas VJ, Magana Torres MT, Gonzalez Garcia JR
- KMID: 2373523
- Ann Lab Med.
- 2016 Mar;36(2):185-187.
- doi: 10.3343/alm.2016.36.2.185
No abstract available. -
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- Novel deletion of the E3A ubiquitin protein ligase gene detected by multiplex ligation-dependent probe amplification in a patient with Angelman syndrome
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Cali F, Ragalmuto , Chiavetta , Calabrese , Fichera M, Vinci M, Ruggeri G, Schinocca , Sturnio M, Romano S, Romano V, Elia M
- KMID: 1115268
- Exp Mol Med.
- 2010 Dec;42(12):842-848.
- doi: 10.3858/emm.2010.42.12.087
Angelman syndrome (AS) is a severe neurobehavioural disorder caused by failure of expression of the maternal copy of the imprinted domain located on 15q11-q13. There are different mechanisms leading to... -
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- Notch signaling in the collecting duct regulates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction in mice
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Choi A, Nam SA, Kim WY, Park SH, Kim H, Yang CW, Kim J, Kim YK
- KMID: 2416004
- Korean J Intern Med.
- 2018 Jul;33(4):774-782.
- doi: 10.3904/kjim.2016.230
BACKGROUND/AIMS: Mind bomb-1 (Mib1) encodes an E3 ubiquitin ligase, which is required for the initiation of Notch signaling. Recently, it was demonstrated that the renal collecting duct plays an important... -
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- Homozygous Exon 4 Deletion in Parkin Gene in a Korean Family with Autosomal Recessive Early Onset Parkinsonism
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Kim JS, Lee KS, Kim YI, Lee KH, Kim HT
- KMID: 1779486
- Yonsei Med J.
- 2003 Apr;44(2):336-339.
- doi: 10.3349/ymj.2003.44.2.336
The gene responsible for autosomal recessive parkinsonism, parkin, has recently been identified on chromosome 6q. It has been shown to be mutated in Japanese and European families, most of whom... -
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- Draft Genome of Toxocara canis, a Pathogen Responsible for Visceral Larva Migrans
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Kong J, Won J, Yoon J, Lee U, Kim JI, Huh S
- KMID: 2367416
- Korean J Parasitol.
- 2016 Dec;54(6):751-758.
- doi: 10.3347/kjp.2016.54.6.751
This study aimed at constructing a draft genome of the adult female worm Toxocara canis using next-generation sequencing (NGS) and de novo assembly, as well as to find new genes... -
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- RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study
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Wang XW, Wei W, Wang WQ, Zhao XY, Guo H, Fang DC
- KMID: 2070058
- Gut Liver.
- 2014 Sep;8(5):487-494.
- doi: 10.5009/gnl13133
BACKGROUND/AIMS: To investigate the differential expression of RING finger (RNF) proteins in Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). METHODS: The differential expression of RNFs in normal esophagus (NE), BE, and... -
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- TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling
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Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M
- KMID: 2418847
- Yonsei Med J.
- 2018 Jan;59(1):43-50.
- doi: 10.3349/ymj.2018.59.1.43
PURPOSE: Tripartite-motif-containing protein 56 (TRIM56) has been found to exhibit a broad antiviral activity, depending upon E3 ligase activity. Here, we attempted to evaluate the function of TRIM56 in multiple... -
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- Axillary Lymph Node-to-Primary Tumor Standard Uptake Value Ratio on Preoperative 18F-FDG PET/CT: A Prognostic Factor for Invasive Ductal Breast Cancer
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Kim YH, Yoon HJ, Kim Y, Kim BS
- KMID: 2374533
- J Breast Cancer.
- 2015 Jun;18(2):173-180.
- doi: 10.4048/jbc.2015.18.2.173
PURPOSE: This study assessed the axillary lymph node (ALN)-to-primary tumor maximum standard uptake value (SUVmax) ratio (ALN/T SUV ratio) in invasive ductal breast cancer (IDC) on preoperative 18F-fluorodeoxyglucose positron emission... -
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