- Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension
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Lee YH, Kim YG, Moon JY, Kim JS, Jeong KH, Lee TW, Ihm CG, Lee SH
- KMID: 2369607
- Electrolyte Blood Press.
- 2016 Dec;14(2):21-26.
- doi: 10.5049/EBP.2016.14.2.21
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the... -
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- In Vitro Release of L-dopa and Dopamine by Genetically Modified Fibroblasts of the Rat
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Chung BS
- KMID: 2187841
- J Korean Neurosurg Soc.
- 1993 Apr;22(4):529-536.
A construct DNA containing the cDNA for rat tyrosine hydroxylase(TH) and another construct DNA containing the cDNA for bovine L-dopa decarboxylase(DDC) were made and those genes were transferred by calcium... -
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- An Association Study between the HUMTH01-VNTR Polymorphism of the Tyrosine Hydroxylase Gene and Schizophrenia
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Jeon T, Kweon Y
- KMID: 2340344
- J Korean Neuropsychiatr Assoc.
- 1999 Jul;38(4):843-852.
OBJECTIVES: To investigate the genetic relation of the Tyrosine Hydroxylase gene, a rate-limiting enzyme in the synthesis of catecholamine, with schizophrenia, we designed the association study between the microsatellite... -
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- Association Study of Tyrosine Hydroxylase and Tryptophan Hydroxylase with Schizophrenia
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Toh KY, Bang SK, Paik IH
- KMID: 2340465
- J Korean Neuropsychiatr Assoc.
- 2000 May;39(3):638-646.
Neurochemical investigation has played a major role in the search for the cause of schizophrenia. Among many hypotheses, dopamine hypothesis of schizophrenia prevails despite much criticism and qualification. Recently, evidences... -
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- Distribution of Tyrosine Hydroxylse Immunoreactive Structure in the Spinal Cord and Dorsal Root Ganglion of the Rat
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Kim YJ, Kim JY, Kim DS, Jo HJ, Bae YC, Park MJ
- KMID: 2224625
- Korean J Anat.
- 1997 Apr;30(2):147-153.
With the aim of gaining more insight into the catecholaminergic system in the nervous system of the rat, we have studied the precise distribution pattern of the tyrosine hydroxylase immunoreactive[TH-IR]... -
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- The Acute Effects of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine on the Inner Plexiform Layer of Rabbits
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Kim DM
- KMID: 2336406
- J Korean Ophthalmol Soc.
- 1987 Apr;28(2):353-362.
The electrophysiological effects of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(NMPTP), a chemical inducer of Parkinsonism in man and monkey, on the pigmented rabbit retina were determined under acute condition. The amplitude of... -
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- Coexistence of Tyrosine Hydroxylase and Nicotinamide Adenine Dinucleotide Phosphate-Diaphorase in Hypothalamic Neurons of the Rat
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Huh YB, Cho JS, Song CS, Ahn HK
- KMID: 2092646
- Korean J Anat.
- 1998 Feb;31(1):119-126.
The presence and coexistence of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-diaphorase) with tyrosine hydroxylase (TH) was investigated by combining NADPH-diaphorase histochemistry with TH immunohistochemistry in hypothalamic nuclei of the rat. TH-immunoreactive... -
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- VNTR Polymorphism of Tyrosine Hydroxylase Gene Intron 1 in Schizophrenics
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Paik IH, Toh KY, Lee CU, Kim JJ, Lee SJ, Lee C
- KMID: 2334616
- J Korean Soc Biol Psychiatry.
- 1999 Nov;6(2):170-175.
Until recently, the etiology of schizophrenia was generally attributed to abnormalities in dopaminergic neurotransmission. Specifically, an excess of dopaminergic activity in the mesolimbic system has been postulated to produce the... -
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- Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism
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Cho CH, Kang SG, Choi JE, Park YM, Lee HJ, Kim L
- KMID: 2315839
- Psychiatry Investig.
- 2009 Sep;6(3):211-215.
OBJECTIVE: Restless legs syndrome (RLS) has been reported to be more prevalent in schizophrenic patients who take antipsychotics. The cause of RLS is unknown but associated with dopaminergic deficiency. Tyrosine... -
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- Tyrosine Hydroxylase, Dopamine-beta-Hydroxylase and Phenylethanolamine-N-Methyltransferase Immunoreactive Neurons of the Medulla Oblongata in the Apodemus agrarius
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Jeong YG, Lee NS, Min SK
- KMID: 1530106
- Korean J Anat.
- 1998 Jun;31(3):419-428.
The distributions and morphological characteristics of neurons displaying immunoreactivity to the catecholamine synthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT) were examined in the adjacent sections of the... -
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- Association Study of Alcohol Dependence with the Tyrosine Hydroxylase Gene Polymorphism
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Jun T, Kim S
- KMID: 2340343
- J Korean Neuropsychiatr Assoc.
- 1999 Jul;38(4):834-842.
OBJECTIVES: To investigate the genetic relation of the tyrosine hydroxylase(TH) a ratelimiting enzyme in the synthesis of catecholamine, with alcohol dependence, we designed the association study between the microsatellite... -
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- No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia
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Lee HJ, Kang SG, Choi JE, Park YM, Lim SW, Rhee MK, Kim SH, Kim L
- KMID: 2315825
- Psychiatry Investig.
- 2009 Jun;6(2):108-111.
OBJECTIVE: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a... -
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- Ectopic Tyrosine Hydroxylase-immunoreactive Neurons in the 6-OHDA-lesioned Striatum in Neonatal Rat
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Hann HJ
- KMID: 1514930
- Korean J Anat.
- 2003 Apr;36(2):89-98.
Tyrosine hydroxylase-immunoreactive (TH-IR) neurons are known to exist in the substantia nigra pars compacta (SNpc), but not in the striatum in normal rats. In this study, injection of 6-OHDA into... -
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- Effects of Cofactor Tetrahydrobiopterin and Deletions on the Regulatory Domain of Tyrosine Hydroxylase on the Expression of Tyrosine Hydroxylase
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Cho YW, Yi SD, Lim JK, Lee H, Kim YS, Lee U, Lee YJ
- KMID: 2342930
- J Korean Neurol Assoc.
- 2001 Sep;19(5):514-519.
BACKGROUND: For the treatment of Parkinson's disease, dopamine-producing cells or genes involved in producing dopamine or supporting neurons have been tested to replace conventional chemical therapies. Of these, tyrosine hydroxylase... -
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- The Effect of MPTP in The Mouse Brain in Relation to Aging: Immunocytochemical Analysis
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Kim JW, Lee SK, Ha KM
- KMID: 2342392
- J Korean Neurol Assoc.
- 1994 Jun;12(2):183-187.
The effect of MPTP on catecholamine neurons in young (4-6 weeks) and aging (10-12 months) C57BL/6 mice was studied using immunocytochemical techniques. Both groups of mice received 4 repeated dosages... -
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- Adrenergic Genetic Mechanisms in Hypertension and Hypertensive Kidney Disease
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Kang SW
- KMID: 2168397
- Electrolyte Blood Press.
- 2013 Jun;11(1):24-28.
- doi: 10.5049/EBP.2013.11.1.24
Catecholamine secretory traits were significantly heritable, as were stress-induced blood pressure changes. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. In the tyrosine hyroxylase promoter, significant associations were... -
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- Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
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Davaasambuu U, Park KH, Park HJ, Choi HS, Lee CK, Hwang BY, Lee MK
- KMID: 2416069
- Nat Prod Sci.
- 2018 Jun;24(2):99-102.
- doi: 10.20307/nps.2018.24.2.99
This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at... -
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- Immunohistochemical Localization of a Dopamine Releasing Protein in Human Brain
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Shin KY, Bae SD, Kim JJ, Nau SM, Kim MO, Cho KJ, Lee BH, Choi WS, Sohn HJ, Baik SH
- KMID: 2377165
- Korean J Phys Anthropol.
- 1994 Dec;7(2):171-186.
- doi: 10.11637/kjpa.1994.7.2.171
In order to elucidate the existence and locality of DARP in the human brain, immunohistochemical identification was done in the brain tissues. This glycoprotein was distributed in paraventricular nucleus and... -
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- Clinical Significance of Tyrosine Hydroxylase mRNA Transcripts in Peripheral Blood at Diagnosis in Patients with Neuroblastoma
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Lee NH, Son MH, Choi YB, Yi E, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2356242
- Cancer Res Treat.
- 2016 Oct;48(4):1399-1407.
- doi: 10.4143/crt.2015.481
PURPOSE: The purpose of this study is to investigate the clinical significance of tyrosine hydroxylase (TH) expression in peripheral blood (PB) at diagnosis in patients with neuroblastoma. MATERIALS AND METHODS: TH... -
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- VNTR Polymorphism of the Tyrosine Hydroxylase in Bipolar Patients
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Kweon YS, Toh KY, Jun TY, Paik IH
- KMID: 2340151
- J Korean Neuropsychiatr Assoc.
- 1998 Mar;37(2):363-371.
OBJECTIVES: Tyrosine hydroxylase(TH) is a rate-limiting enzyme in the synthesis of catecholamines, and could be a candidate gene for causing the bipolar disorders. Therefore, we designed this study to investigate... -
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