- Loss of PTEN Expression in Primary Lung Cancer
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Roh MS
- KMID: 2275559
- Korean J Pathol.
- 2002 Oct;36(5):286-291.
BACKGROUND: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene, a candidate tumor suppressor, is localized to chromosome 10q23 and shares extensive homology with cytoskeletal proteins auxilin and... -
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- Human Papillomavirus Infection
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Park JS
- KMID: 2416597
- J Korean Med Assoc.
- 2002 Apr;45(4):430-442.
- doi: 10.5124/jkma.2002.45.4.430
The pathogenesis of cervical cancer is a clinically important example of multistage epithelial tumorigenesis from the progressive neoplastic changes known as premalignant cervical intraepithelial neoplasias (CINs) to invasive cervical cancers.... -
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- CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells
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Liu X, Chong Y, Liu H, Han Y, Niu M
- KMID: 2388672
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):161-168.
- doi: 10.4196/kjpp.2016.20.2.161
Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated... -
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- The function of p27(KIP1) during tumor development
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Lee J, Kim SS
- KMID: 1122277
- Exp Mol Med.
- 2009 Nov;41(11):765-771.
- doi: 10.3858/emm.2009.41.11.102
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which... -
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- Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
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Kang Y, Jung WY, Lee H, Lee E, Kim A, Kim BH
- KMID: 2012052
- Korean J Pathol.
- 2012 Dec;46(6):523-531.
BACKGROUND: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with... -
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- Expression of Human Papillomavirus 16/18 E6/E7 , p53 and Rb Proteins according to Progression of Cancerous Lesions of the Uterine Cervix
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Jang KH, Lee KW, Yeom BW
- KMID: 2260918
- Korean J Obstet Gynecol.
- 1998 Apr;41(4):1075-1086.
Human papillomavirus (HPV) infection in women is known to be a causative factor in the initiation and progression of uterine cervical cancer by producing proteins in host cells to effect... -
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- p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest
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Chae HD, Kim SY, Park SE, Kim J, Shin DY
- KMID: 1245266
- Exp Mol Med.
- 2012 Mar;44(3):236-240.
- doi: 10.3858/emm.2012.44.3.018
We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin... -
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- Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA
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Choi JY, Yun WB, Kim JE, Lee MR, Park JJ, Song BR, Kim HR, Park JW, Kang MJ, Kang BC, Lee HW, Hwang DY
- KMID: 2420824
- Lab Anim Res.
- 2018 Sep;34(3):118-125.
- doi: 10.5625/lar.2018.34.3.118
To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor suppressor proteins,... -
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- Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis
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Kim HS, Shen Q, Nam SW
- KMID: 2344168
- J Korean Med Sci.
- 2015 Oct;30(10):1375-1380.
- doi: 10.3346/jkms.2015.30.10.1375
A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of... -
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- Promoter Methylation of CDKN2A, RARbeta, and RASSF1A in Non-Small Cell Lung Carcinoma: Quantitative Evaluation Using Pyrosequencing
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Lee JU, Sul HJ, Son JW
- KMID: 2050670
- Tuberc Respir Dis.
- 2012 Jul;73(1):11-21.
- doi: 10.4046/trd.2012.73.1.11
BACKGROUND: While qualitative analysis of methylation has been reviewed, the quantitative analysis of methylation has rarely been studied. We evaluated the methylation status of CDKN2A, RARbeta, and RASSF1A promoter regions... -
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- Inactivation of p73 Protein by Cervical Cancer-inducing HPV E6 Protein Novel p53-independent function of E6
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Namkoong S, Kim SJ, Kim EJ, Um SJ, Park JS
- KMID: 2026746
- Korean J Obstet Gynecol.
- 1998 Nov;41(11):2827-2834.
OBJECTIVE: Human papillomavirus (HPV) is strongly implicated as a causative agent in the etiology of cervical cancer. Of its gene products, E6 and E7 oncoproteins play major roles by inactivation... -
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- Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death
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Choi SC, Yoon SR, Park YP, Song EY, Kim JW, Kim WH, Yang Y, Lim JS, Lee HG
- KMID: 1091065
- Exp Mol Med.
- 2007 Dec;39(6):705-714.
Although N-myc downstream regulated gene 2 (NDRG2) has been known to be a tumor suppressor gene, the function of this gene has not been elucidated. In the present study, we... -
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- Comparison of Methylation Profiling in Cancerous and Their Corresponding Normal Tissues from Korean Patients with Breast Cancer
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Jung EJ, Kim IS, Lee EY, Kang JE, Lee SM, Kim DC, Kim JY, Park ST
- KMID: 1711317
- Ann Lab Med.
- 2013 Nov;33(6):431-440.
- doi: 10.3343/alm.2013.33.6.431
BACKGROUND: Aberrant DNA hypermethylation plays a pivotal role in carcinogenesis and disease progression; therefore, accurate measurement of differential gene methylation patterns among many genes is likely to reveal biomarkers for... -
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- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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- Expressions of Cell Cycle Control Genes in Human Uterine Cervical Cancer Cells
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Ahn JG, Lee TS, Cho JW, Baek WK, Suh SI, Suh MH, Park JW, Cha SD
- KMID: 2137118
- J Korean Cancer Assoc.
- 2000 Feb;32(1):110-119.
PURPOSE: Recently, many aspects of biological functions of cyclins, cyclin-dependent kinases (CDKs), CDK inhibitors and Rb gene have been reported, and the cell cycle control genes are considered to act important roles in... -
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- Netrin-1 Specifically Enhances Cell Spreading on Fibronectin in Human Glioblastoma Cells
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Lee HK, Seo IA, Shin YK, Lee SH, Seo SY, Suh DJ, Park HT
- KMID: 1486103
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):225-230.
- doi: 10.4196/kjpp.2008.12.5.225
Netrins are secreted molecules and involved in axon guidance, cell migration and tumor development. Recent studies revealed that netrins perform novel functions in such processes as epithelial development and angiogenesis... -
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- Cyclin E, p27 and Mutant p53 do not Predict the Prognosis in AJCC Stage II Colorectal Carcinomas
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Lim YJ, Kim YH, Ahn GH, Chun HK, Jang WY, Lee JH, Son HJ, Rhee PL, Kim JJ, Paik SW, Yoo BC, Rhee JC
- KMID: 772703
- Korean J Gastroenterol.
- 2004 Dec;44(6):314-320.
BACKGROUND/AIMS: Carcinogenesis is characterized by the abnormal regulation of cell cycle. The abnormal expression of the regulators of cell cycle may be related to the prognosis. Since the clinical... -
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- Metaplastic Squamous Carcinoma of the Breast: Clinicopathologic Analysis of 17 Cases
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Lee SA, Lee KE, Moon BI, Han WS, Sung SH
- KMID: 1472550
- Korean J Pathol.
- 2009 Feb;43(1):20-25.
- doi: 10.4132/KoreanJPathol.2009.43.1.20
BACKGROUND: Squamous cell carcinoma of the breast is very rare and it is considered to arise from metaplastic change of ductal carcinoma. Metaplastic squamous cell carcinoma (MSC) of the breast... -
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- The Expression of ERCC1, RRM1, and BRCA1 in Breast Cancer According to the Immunohistochemical Phenotypes
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Kim D, Jung W, Koo JS
- KMID: 2157871
- J Korean Med Sci.
- 2011 Mar;26(3):352-359.
- doi: 10.3346/jkms.2011.26.3.352
We studied the expression of BRCA1, ERCC1, and RRM1 which play an important role in DNA repair systems in breast cancer. Immunohistochemical staining for EGFR, BRCA1, ERCC1, and RRM1 were... -
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- Integrative epigenomic and genomic analysis of malignant pheochromocytoma
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Sandgren J, Andersson , Rada-Iglesias A, Enroth S, Akerstrom , Dumanski J, Komorowski J, Westin G, Wadelius C
- KMID: 1104209
- Exp Mol Med.
- 2010 Jul;42(7):484-502.
- doi: 10.3858/emm.2010.42.7.050
Epigenomic and genomic changes affect gene expression and contribute to tumor development. The histone modifications trimethylated histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) are epigenetic regulators associated to... -
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