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The Eosinophilia-Myalgia Syndrome not Associated with L-tryptophan: A case report

Han TR, Kim JH, Lim JY, Lim SJ

  • KMID: 2136810
  • J Korean Acad Rehabil Med.
  • 1998 Aug;22(4):983-988.
We report a case of clinical features corresponding to Eosinophilia-Myalgia syndrome, with no causal relationship with L-tryptophan. Since the epidemic of L-tryptophan associated Eosinoghilia-Myalgia Syndrome in 1989, only 2% of...
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Acute Tryptophan Depletion and Functional Brain Imaging in Irritable Bowel Syndrome (Gut 2011;60:1196-1203)

Kim HM

  • KMID: 2325869
  • J Neurogastroenterol Motil.
  • 2012 Jan;18(1):106-108.
No abstract available.
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The Effect of Treatment with Tryptophan and/or Imipramine on the Serotonergic Immunoreactivity in Raphe Nucleus of Midbrain of the Rats

Kim MS, Lee CH

  • KMID: 1559168
  • Korean J Anat.
  • 2002 Feb;35(1):83-90.
These experiments were performed to investigate the effect of saline, tryptophan, tryptophan-imipramine and/or imipramine on serotonin immunoreactivity in raphe nucleus of midbrain of the rats (180~200 g, body weight). The...
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Eosinophilia-Myalgia Syndrome not Associated with the Ingestion of Nutritional Supplements

Ahn SW, Shin BJ, Seo SJ, Hong CK

Eosinophilia-myalgia syndrome(EMS) is a systemic illness that occurred as an epidemic by ingestion of over-the counter L-tryptophan preparation in the United States in October 1989. We report a Korean case of...
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The effect of treatment with tryptophan and/or reserpine on the serotonergic immunoreactivity in raphe nucleus of medulla oblongata and midbrain of the rats

Kim MS, Lee CH

  • KMID: 2030737
  • Korean J Anat.
  • 2001 Feb;34(1):33-40.
The present study was carried out to investigate the effect of treatment with tryptophan and/or reserpine on the raphe of medulla oblongata and mid brain of the rats (180~200 g...
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Central Nervous System Involvement in Eosinophilia-Myalgia Syndrome Associated with L-tryptophan Ingestion: A case report

Lee CH, Lee SH, Kim SJ

  • KMID: 2058319
  • J Korean Acad Rehabil Med.
  • 1998 Dec;22(6):1347-1351.
We report a case of Eosinophilia- Myalgia syndrome with central nervous system (CNS) involvement following ingestion of the essential amino acid, tryptophan. The Eosinophilia- Myalgia syndrome can be diagnosed when...
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A Comparison of Inhibitory Effects in Brown and White Rice (Oryza sativa L.) against Mutagenicity Induced by Tryptophan Pyrolysates

You JE, Chun HS, Cho JS

  • KMID: 2331839
  • J Korean Diet Assoc.
  • 1997 Aug;3(2):105-111.
The inhibitory effect of rice(Oryza sartiva L., illpumbyeo) against mutagenicity induced by tryptophan pyrolysates were investigated using Salmonella typhimurium reversion assay. Both methanol extracts of obtained from brown and white...
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The tryptophan utilization concept in pregnancy

Badawy AA

The decrease in maternal plasma total (free + albumin-bound) tryptophan (Trp) during the third pregnancy trimester is attributed to induction of indoleamine 2,3-dioxygenase (IDO). When measured, free [Trp] is increased...
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The Effect of Treatment with Imipramine and/or Tryptophan after Chronic Stress on the Serotonergic Immunoreactivity in Rat Raphe Nucleus

Kim MS, Lee CH

  • KMID: 1559383
  • Korean J Anat.
  • 2002 Oct;35(5):453-462.
These experiments were performed to investigate the effect of saline, stress, imipramine, stress -imipramine and/or stress -tryptophan on serotonin immunoreactivity in raphe nucleus of the rats (200 ~220 g, body...
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Biosynthetic Pathway of Indole-3-Acetic Acid in Basidiomycetous Yeast Rhodosporidiobolus fluvialis

Bunsangiam S, Sakpuntoon V, Srisuk N, Ohashi T, Fujiyama K, Limtong S

IAA biosynthetic pathways in a basidiomycetous yeast, Rhodosporidiobolus fluvialis DMKU-CP293, were investigated. The yeast strain showed tryptophan (Trp)-dependent IAA biosynthesis when grown in tryptophan supplemented mineral salt medium. Gas chromatography–mass...
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Acute Effect of Alcohol and Nicotine on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal and Median Raphe of Rats

Jang MH, Shin MC, Chang HK, Lee TH, Kim KH, Kim YJ, Kim CJ

  • KMID: 1607347
  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):5-8.
Alcohol abuse and cigarette smoking have been on the rise worldwide and it has been reported that alcohol and nicotine influence serotonergic neuronal activity in the dorsal raphe. Serotonin (5-hydroxytryptamine,...
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Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation

Silwal P, Shin K, Choi S, Namgung U, Lee CY, Heo JY, Lim K, Park JI, Kim KH, Park SK

Mast cells are major immune cells in allergy to secrete allergic mediators by a degranulation process and make and secrete inflammatory lipids and cytokines in response to antigen stimulation. An...
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An Association Study of Schizophrenics and Their Clinical Variables with Tryptophan Hydroxylase Gene Polymorphism

Cho HS, Lee SP, Toh KY, Paik IH

  • KMID: 2340371
  • J Korean Neuropsychiatr Assoc.
  • 1999 Sep;38(5):1130-1136.
OBJECTIVES: The genetic polymorphism of tryptophan hydroxylase (TPH) the rate-limiting enzyme in the biosynthesis of serotonin, has been to be related with various psychiatric disorders such as bipolar disorders....
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Hypericum Perforatum Decreased Hippocampus TNF-alpha and Corticosterone Levels with No Effect on Kynurenine/Tryptophan Ratio in Bilateral Ovariectomized Rats

El-Bakly W, Hasanin AH

The present study was designed to investigate the effect Hypericum Perforatum (HP), on behavioral changes, corticosterone, TNF-alpha levels and tryptophan metabolism and disposition in bilateral ovariectomized rats compared to 17alpha...
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New Avenues in the LRP5-mediated Bone Mass Acquisition

Choi JY

Lipoprotein receptor-related protein (LRP5) signaling is well correlated with the bone mass in both human and mice. Loss-of-function mutations of LRP5 result in osteopenia or osteoporosis. In contrast, gain-of-function mutations...
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Fluoxetine-induced Changes on Activity of Tryptophan Hydroxylase at RBL-2H3 Cells

Baik SY, Jung KH, Choi MR, Yang BH, Kim SH, Choi IG, Chai YG

  • KMID: 2286983
  • Korean J Psychopharmacol.
  • 2004 Dec;15(4):449-456.
OBJECTIVES: The aim of the present study is to explore the effect of fluoxetine on transcription, translation and activity of tryptophan hydroxylase (TPH), and intracellular level of serotonin. METHODS: The...
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Association Study of Tyrosine Hydroxylase and Tryptophan Hydroxylase with Schizophrenia

Toh KY, Bang SK, Paik IH

  • KMID: 2340465
  • J Korean Neuropsychiatr Assoc.
  • 2000 May;39(3):638-646.
Neurochemical investigation has played a major role in the search for the cause of schizophrenia. Among many hypotheses, dopamine hypothesis of schizophrenia prevails despite much criticism and qualification. Recently, evidences...
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A Case of Eosinphilia-Myalgia Syndrome

Kim JW, Choi SJ, Jung HJ, Ji JD, Lee YH, Song GG

  • KMID: 2202523
  • J Korean Rheum Assoc.
  • 1999 Jun;6(2):157-161.
Eosinophilia-myalgia syndrome (EMS) is a multisystemic disorder characterized by severe myalgia and peripheral eosinophilia, and frequently accompanied by fasciitis, neuropathy and various cutaneous manifestations associated with consumption of L-tryptophan. Although...
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The Tryptophan Hydroxylase A218C Polymorphism in Patients with Bipolar Disorder

Kim WT, Kim SK

  • KMID: 2286805
  • Korean J Psychopharmacol.
  • 2005 Sep;16(5):406-415.
OBJECTIVE: This study has been carried out to explore the genetic causes of bipolar disorder by comparing the frequency of Tryptophan Hydroxylase (TPH) A218C polymorphism between bipolar disorder patients and...
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Polymorphism of Tryptophan Hydroxylase Gene in Alcohol Dependent Patients

Hong JB, Lee SI, Shin CJ, Kim H, Chi KW, Chung IW

  • KMID: 2364341
  • J Korean Neuropsychiatr Assoc.
  • 2001 Jul;40(4):718-726.
OBJECTIVES: This study was performed to explore the association of tryptophan hydroxylase(TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity...
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